Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 8/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 8/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 8/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 8/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 8/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 8/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3535415 | 1.00 | NPC1 (0.35) | NPC1RAB9ATSHRSMN1; SMN2PSEN1 | |
| Formic Acid SCHEMBL3536155 | 0.94 | TSHR (0.34) | NPC1RAB9ATSHRSMN1; SMN2PSEN1 | |
| SCHEMBL3542463 | 0.82 | NPC1 (0.33) | NPC1RAB9ATSHRSMN1; SMN2PSEN1 | |
| SCHEMBL13314766 | 0.82 | NPC1 (0.33) | NPC1RAB9ATSHRSMN1; SMN2PSEN1 | |
| SCHEMBL3536165 | 0.81 | NPC1 (0.34) | NPC1RAB9ATSHRPSEN1PSEN2 | |
| SCHEMBL3536663 | 0.81 | NPC1 (0.34) | NPC1RAB9ATSHRPSEN1PSEN2 | |
| SCHEMBL3536160 | 0.80 | TSHR (0.34) | NPC1RAB9ATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL3536953 | 0.80 | XIAP (0.36) | NPC1RAB9ATSHRSMN1; SMN2PSEN1 | |
| SCHEMBL13349056 | 0.80 | NPC1 (0.33) | NPC1RAB9ATSHRSMN1; SMN2PSEN1 | |
| SCHEMBL3538767 | 0.79 | PSEN1 (0.33) | NPC1RAB9ATSHRPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7727979-B2 | Guanidine derivatives and their use as neuropeptide FF receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-06-01 | — | — | US | disclosed |
| US-7727979-B2 | Guanidine derivatives and their use as neuropeptide FF receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-06-01 | — | — | US | disclosed |