Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.44 |
| ▸ | LMNA | P02545 | 8/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3533584 | 1.00 | MAPT (0.44) | MAPTLMNATP53THRBNPSR1 | |
| Formic Acid SCHEMBL3533007 | 0.96 | MAPT (0.42) | MAPTLMNATP53THRBNPSR1 | |
| SCHEMBL3538231 | 0.86 | MAPT (0.42) | MAPTLMNATP53THRBNPSR1 | |
| SCHEMBL13314838 | 0.86 | MAPT (0.42) | MAPTLMNATP53THRBNPSR1 | |
| Formic Acid SCHEMBL3542530 | 0.84 | MAPT (0.41) | MAPTLMNATP53THRBNPSR1 | |
| SCHEMBL3536226 | 0.81 | MAPT (0.61) | MAPTLMNATP53THRBNPSR1 | |
| SCHEMBL13314768 | 0.81 | MAPT (0.61) | MAPTLMNATP53THRBNPSR1 | |
| SCHEMBL13314851 | 0.77 | LMNA (0.46) | MAPTLMNATP53THRBALDH1A1 | |
| SCHEMBL3534984 | 0.77 | LMNA (0.46) | MAPTLMNATP53THRBALDH1A1 | |
| SCHEMBL3536735 | 0.76 | NPC1 (0.47) | MAPTLMNATP53THRBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7727979-B2 | Guanidine derivatives and their use as neuropeptide FF receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-06-01 | — | — | US | disclosed |
| US-7727979-B2 | Guanidine derivatives and their use as neuropeptide FF receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-06-01 | — | — | US | disclosed |