Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 3/20 | 0.62 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | DHPS | P49366 | 1/20 | 0.32 |
| ▸ | FNTA | P49354 | 4/20 | 0.32 |
| ▸ | FNTB | P49356 | 4/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | FPR1 | P21462 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13316216 | 0.92 | CYP11B1 (0.52) | CYP11B2CYP11B1CYP3A4FNTAFNTB | |
| SCHEMBL13316215 | 0.91 | CYP11B2 (0.52) | CYP11B2CYP11B1CYP3A4FNTAFNTB | |
| SCHEMBL13316213 | 0.91 | CYP11B2 (0.52) | CYP11B2CYP11B1CYP3A4KCNH2 | |
| SCHEMBL13316217 | 0.91 | CYP11B1 (0.51) | CYP11B2CYP11B1CYP3A4TSHRFNTA | |
| SCHEMBL13316218 | 0.89 | CYP11B1 (0.49) | CYP11B2CYP11B1CYP3A4TSHRMEN1 | |
| SCHEMBL3572398 | 0.86 | CYP11B2 (0.79) | CYP11B2CYP11B1CYP3A4HPGDTSHR | |
| SCHEMBL3578304 | 0.85 | CYP11B2 (0.66) | CYP11B2CYP11B1CYP3A4HPGDTSHR | |
| Hydrochloric Acid SCHEMBL3572437 | 0.85 | CYP11B2 (0.78) | CYP11B2CYP11B1CYP3A4HPGDTSHR | |
| SCHEMBL13316220 | 0.85 | CYP11B1 (0.43) | CYP11B2CYP11B1FNTAFNTBPGGT1B | |
| SCHEMBL3577749 | 0.85 | CYP11B1 (0.65) | CYP11B2CYP11B1CYP3A4HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7732603-B2 | Organic compounds as agents for the treatment of aldosterone mediated conditions | NOVARTIS AG (CH) | 2010-06-08 | — | — | US | disclosed |