Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CPN1 | P15169 | 1/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | UGT2B7 | P16662 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13316253 | 0.85 | CPN1 (0.35) | SLC6A2SLC6A4SLC6A3CPN1CPB2 | |
| SCHEMBL13316254 | 0.80 | CPN1 (0.41) | SLC6A2SLC6A4SLC6A3CPN1CPB2 | |
| SCHEMBL13316244 | 0.78 | DPP4 (0.42) | GAAPKMALDH1A1KDM4ELMNA | |
| SCHEMBL3602265 | 0.77 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3CYP2D6CPN1 | |
| SCHEMBL15534191 | 0.76 | MGAM (0.44) | CYP2D6SMYD3GAAMGAMSI | |
| SCHEMBL27108548 | 0.76 | CPN1 (0.34) | SLC6A2SLC6A4SLC6A3CPN1CPB2 | |
| SCHEMBL27742204 | 0.75 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3CYP2D6CPN1 | |
| SCHEMBL13349503 | 0.74 | CPN1 (0.32) | CPN1CPB2 | |
| SCHEMBL11395732 | 0.70 | L3MBTL1 (0.53) | SLC6A2SLC6A4SLC6A3CPN1CPB2 | |
| SCHEMBL13316249 | 0.70 | CPN1 (0.34) | SLC6A2SLC6A4SLC6A3CPN1CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160306-A1 | Acylated Piperidine Derivatives as Melanocortin-4 Receptor Agonists | MERCK SHARP & DOHME CORP. | 2010-06-24 | — | — | US | disclosed |
| US-20100160306-A1 | Acylated Piperidine Derivatives as Melanocortin-4 Receptor Agonists | MERCK SHARP & DOHME CORP. | 2010-06-24 | — | — | US | disclosed |
| US-7618987-B2 | Acylated piperidine derivatives as melanocortin 4-receptor agonists | MERCK & CO., INC. (US) | 2009-11-17 | — | — | US | disclosed |
| US-7618987-B2 | Acylated piperidine derivatives as melanocortin 4-receptor agonists | MERCK & CO., INC. (US) | 2009-11-17 | — | — | US | disclosed |
| US-20070191433-A1 | Acylated piperidine derivatives as melanocortin 4-receptor agonists | MERCK SHARP & DOHME CORP. | 2007-08-16 | — | — | US | disclosed |
| US-20070191433-A1 | Acylated piperidine derivatives as melanocortin 4-receptor agonists | MERCK SHARP & DOHME CORP. | 2007-08-16 | — | — | US | disclosed |
| WO-2007041061-A2 | ACYLATED PIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS | MERCK & CO., INC. (US) | 2007-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160306-A1 | Acylated Piperidine Derivatives as Melanocortin-4 Receptor Agonists | MC4R, MC5R, MC3R | SLC6A2 569/4885SLC6A4 165/4885SLC6A3 383/4885 |
| US-20070191433-A1 | Acylated piperidine derivatives as melanocortin 4-receptor agonists | MC4R, MC5R, MC3R | SLC6A2 1237/4885SLC6A4 372/4885SLC6A3 886/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.