Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.98 |
| ▸ | ABCB1 | P08183 | 15/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.71 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.71 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.71 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.71 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.71 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.71 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.71 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.71 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.71 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.71 |
| ▸ | HTR2A | P28223 | 1/20 | 0.71 |
| ▸ | HTR2C | P28335 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diprafenone SCHEMBL563653 | 0.90 | MEN1 (0.80) | MEN1KMT2AABCB1LMNACYP1A2 | |
| Diprafenone SCHEMBL8862790 | 0.89 | MEN1 (0.82) | MEN1KMT2AABCB1LMNACYP1A2 | |
| SCHEMBL15750367 | 0.87 | ABCB1 (0.77) | MEN1KMT2AABCB1LMNACYP1A2 | |
| SCHEMBL31619332 | 0.85 | KCNH2 (0.85) | MEN1KMT2AABCB1LMNACYP1A2 | |
| SCHEMBL11583776 | 0.85 | MEN1 (0.72) | MEN1KMT2AABCB1ADRB2ADRB1 | |
| SCHEMBL11867197 | 0.84 | MEN1 (0.71) | MEN1KMT2ACYP1A2CYP2D6KCNH2 | |
| SCHEMBL29439280 | 0.84 | ABCB1 (1.00) | MEN1KMT2AABCB1LMNACYP1A2 | |
| Propafenone SCHEMBL27865 | 0.83 | ABCB1 (1.00) | MEN1KMT2AABCB1LMNACYP1A2 | |
| Propafenone SCHEMBL41413 | 0.83 | ABCB1 (1.00) | MEN1KMT2AABCB1LMNACYP1A2 | |
| Propafenone SCHEMBL16730120 | 0.83 | ABCB1 (1.00) | MEN1KMT2AABCB1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8323911-B2 | High throughput assay for discovering new inhibitors of the GIRK1/4 channel | UNIVERSITY OF SOUTH CAROLINA (US) | 2012-12-04 | — | — | US | disclosed |
| US-20110281278-A1 | High Throughput Assay for Discovering New Inhibitors of the GIRK1/4 Channel | UNIVERSITY OF SOUTH CAROLINA (US) | 2011-11-17 | — | — | US | disclosed |