Known targets — ChEMBL curated mechanism
ADRB1ADRB2SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Propafenone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 1.00 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 1.00 |
| ▸ | SCN5A known ✓ | Q14524 | 1/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 17/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | KCNK3 | O14649 | 1/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 1/20 | 1.00 |
| ▸ | ABCC9 | O60706 | 1/20 | 1.00 |
| ▸ | KCNK2 | O95069 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | ADRB3 | P13945 | 1/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | HTR2C | P28335 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propafenone SCHEMBL27865 | 1.00 | ABCB1 (1.00) | ABCB1LMNACYP1A2CYP2D6CYP3A4 | |
| Propafenone SCHEMBL30416841 | 1.00 | ABCB1 (1.00) | ABCB1LMNACYP1A2CYP2D6CYP3A4 | |
| Propafenone SCHEMBL16730120 | 1.00 | ABCB1 (1.00) | ABCB1LMNACYP1A2CYP2D6CYP3A4 | |
| Propafenone SCHEMBL29384899 | 0.99 | MEN1 (1.00) | ABCB1LMNACYP1A2CYP2D6CYP3A4 | |
| Propafenone SCHEMBL41412 | 0.99 | MEN1 (1.00) | ABCB1LMNACYP1A2CYP2D6CYP3A4 | |
| Propafenone SCHEMBL5529275 | 0.99 | MEN1 (1.00) | ABCB1LMNACYP1A2CYP2D6CYP3A4 | |
| Propafenone SCHEMBL1651012 | 0.98 | ABCB1 (0.96) | ABCB1LMNACYP1A2CYP2D6CYP3A4 | |
| SCHEMBL29419081 | 0.94 | ABCB1 (0.88) | ABCB1LMNACYP1A2CYP2D6CYP3A4 | |
| Propafenone SCHEMBL15539494 | 0.91 | ABCB1 (0.83) | ABCB1LMNACYP1A2CYP2D6CYP3A4 | |
| Propafenone SCHEMBL924632 | 0.89 | ABCB1 (0.79) | ABCB1LMNACYP1A2CYP2D6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2103 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120142496-A | Method for detecting impurities in propafenone hydrochloride injection | 华夏生生药业(北京)有限公司 | 2025-06-13 | — | — | CN | claimed |
| CN-119656148-A | Pharmaceutical composition of propafenone or salt thereof and preparation method thereof | 北京市新里程医药科技有限公司 | 2025-03-21 | — | — | CN | claimed |
| CN-119235802-A | Proprazone hydrochloride tablet production and processing technology | 江苏神龙药业有限公司 | 2025-01-03 | — | — | CN | claimed |
| CN-118593442-A | Propafenone hydrochloride tablet and preparation method thereof | 浙江亚太药业股份有限公司 | 2024-09-06 | — | — | CN | claimed |
| CN-118021718-B | Propafenone hydrochloride injection and preparation method thereof | 成都瑞尔医药科技有限公司 | 2024-07-02 | — | — | CN | claimed |
| CN-117462502-B | Propafenone hydrochloride sustained-release composition and preparation method thereof | 山东丰金生物医药有限公司 | 2024-06-11 | — | — | CN | claimed |
| CN-117338741-B | Single-chamber osmotic pump tablet for treating arrhythmia and preparation method and application thereof | 江苏神华药业有限公司 | 2024-05-24 | — | — | CN | claimed |
| CN-118021718-A | Propafenone hydrochloride injection and preparation method thereof | 成都瑞尔医药科技有限公司 | 2024-05-14 | — | — | CN | claimed |
| CN-117731642-A | Propafenone hydrochloride sustained-release capsule and preparation method thereof | 南通联亚药业股份有限公司 | 2024-03-22 | — | — | CN | claimed |
| CN-117462502-A | Novel propafenone hydrochloride sustained-release composition and preparation method thereof | 山东丰金生物医药有限公司 | 2024-01-30 | — | — | CN | claimed |
| EP-1119345-A1 | ENCAPSULATION OF SENSITIVE LIQUID COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE SHELF-STABLE PARTICLES | GENERAL MILLS, INC. (US) | 2001-08-01 | — | — | EP | claimed |
| WO-2000021504-A1 | ENCAPSULATION OF SENSITIVE LIQUID COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE SHELF-STABLE PARTICLES | GENERAL MILLS, INC. (US) | 2000-04-20 | — | — | WO | claimed |
| EP-0935523-A4 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | GEN MILLS INC (US) | 1999-12-29 | — | — | EP | claimed |
| EP-0935523-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | GENERAL MILLS, INC. (US) | 1999-08-18 | — | — | EP | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| WO-1998018610-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | LENGERICH BERNHARD H VAN (US) | 1998-05-07 | — | — | WO | claimed |
| US-5700410-A | Method of manufacturing wax matrices | NIPPON SHINYAKU CO., LTD. (JP) | 1997-12-23 | — | — | US | claimed |
| US-5681588-A | Delayed release microtablet of β-phenylpropiophenone derivatives | KNOLL AKTIENGESELLSCHAFT (DE) | 1997-10-28 | — | — | US | claimed |
| EP-0580860-B1 | METHOD OF MANUFACTURING SOLID DISPERSION | NIPPON SHINYAKU CO LTD (JP) | 1997-10-22 | — | — | EP | claimed |
| EP-0691843-B1 | RETARDED-ACTION MICROTABLET MADE OF BETA-PHENYLPROPIOPHENONE DERIVATIVES | KNOLL AG (DE) | 1997-02-19 | — | — | EP | claimed |