Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CFD | P00746 | 8/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13316624 | 0.91 | KLKB1 (0.41) | METTL3PDE3BPDE3AHPGDLMNA | |
| SCHEMBL3624155 | 0.88 | METTL3 (0.42) | METTL3CFDMRGPRX4PDE4APDE4B | |
| SCHEMBL3620368 | 0.85 | PDE3B (0.43) | PDE3BPDE3AHPGDLMNAKDM4E | |
| SCHEMBL3627969 | 0.83 | PDE3B (0.41) | METTL3PDE3BPDE3AHPGDLMNA | |
| SCHEMBL3618515 | 0.83 | METTL3 (0.44) | METTL3CFDMRGPRX4KLKB1 | |
| SCHEMBL3623481 | 0.82 | METTL3 (0.41) | METTL3CFDKLKB1PDE4APDE4B | |
| SCHEMBL13316622 | 0.82 | PDE3B (0.41) | PDE3BPDE3AHPGDKDM4EALDH1A1 | |
| SCHEMBL3628451 | 0.82 | METTL3 (0.42) | METTL3CFDMRGPRX4KLKB1PDE4A | |
| SCHEMBL13316644 | 0.81 | PDE3B (0.41) | METTL3PDE3BPDE3AHPGDKDM4E | |
| SCHEMBL3624017 | 0.81 | METTL3 (0.43) | METTL3CFDKLKB1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745459-B2 | Quinolizinone compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2010-06-29 | — | — | US | disclosed |
| US-7745459-B2 | Quinolizinone compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2010-06-29 | — | — | US | disclosed |