Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.37 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CMA1 | P23946 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3624978 | 0.90 | METTL3 (0.44) | MRGPRX4METTL3KLKB1CMA1 | |
| SCHEMBL3620368 | 0.87 | PDE3B (0.43) | MRGPRX4ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL13316622 | 0.84 | PDE3B (0.41) | MRGPRX4ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL13316644 | 0.83 | PDE3B (0.41) | MRGPRX4ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL3627969 | 0.83 | PDE3B (0.41) | MRGPRX4ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL13316621 | 0.83 | PDE3B (0.40) | MRGPRX4ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL13316642 | 0.80 | PDE3B (0.38) | MRGPRX4ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL3625716 | 0.80 | PDE3B (0.41) | MRGPRX4ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL13316620 | 0.79 | METTL3 (0.39) | MRGPRX4ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL13316648 | 0.79 | PDE3B (0.38) | MRGPRX4ALDH1A1KDM4EGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745459-B2 | Quinolizinone compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2010-06-29 | — | — | US | disclosed |
| US-7745459-B2 | Quinolizinone compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2010-06-29 | — | — | US | disclosed |