Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Etoposide Phosphate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A known ✓ | P11388 | 5/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.65 |
| ▸ | LMNA | P02545 | 6/20 | 0.65 |
| ▸ | GAA | P10253 | 5/20 | 0.65 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.65 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Etoposide Phosphate SCHEMBL13318135 | 0.96 | CYP3A4 (0.70) | CYP3A4SMN1; SMN2LMNAGAATOP2A | |
| Etoposide Phosphate SCHEMBL13318134 | 0.95 | CYP3A4 (0.60) | CYP3A4SMN1; SMN2LMNAGAATOP2A | |
| Etoposide Phosphate SCHEMBL13318131 | 0.94 | CYP3A4 (0.58) | CYP3A4SMN1; SMN2LMNAGAATOP2A | |
| Etoposide Phosphate SCHEMBL13318140 | 0.93 | CYP3A4 (0.75) | CYP3A4SMN1; SMN2LMNAGAATOP2A | |
| Etoposide SCHEMBL13318180 | 0.92 | CYP3A4 (0.77) | CYP3A4SMN1; SMN2LMNAGAATOP2A | |
| Etoposide Phosphate SCHEMBL13318132 | 0.91 | CYP3A4 (0.65) | CYP3A4SMN1; SMN2LMNAGAATOP2A | |
| Etoposide Phosphate SCHEMBL13318137 | 0.90 | CYP3A4 (0.64) | CYP3A4SMN1; SMN2LMNAGAATOP2A | |
| Etoposide Phosphate SCHEMBL13318136 | 0.90 | CYP3A4 (0.64) | CYP3A4SMN1; SMN2LMNAGAATOP2A | |
| Etoposide Phosphate SCHEMBL13318139 | 0.89 | CYP3A4 (0.67) | CYP3A4SMN1; SMN2LMNAGAATOP2A | |
| Etoposide Phosphate SCHEMBL13318125 | 0.89 | CYP3A4 (0.54) | CYP3A4SMN1; SMN2LMNAGAATOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100143296-A1 | PODOPHYLLOTOXIN INHIBITORS OF TOPOISOMERASE II | AUSPEX PHARMACEUTICALS, INC. (US) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100143296-A1 | PODOPHYLLOTOXIN INHIBITORS OF TOPOISOMERASE II | TOP2A, TOP2B, TOP1 | TOP2A 1/4885CYP3A4 2005/4885SMN1; SMN2 4084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.