Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CPT1A | P50416 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GNRHR | P30968 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13319040 | 0.91 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPK1ALDH1A1HTTKDM4E | |
| SCHEMBL13319301 | 0.84 | CYP3A4 (0.53) | SMN1; SMN2MAPK1ALDH1A1HTTKDM4E | |
| SCHEMBL13319305 | 0.78 | CYP3A4 (0.51) | SMN1; SMN2MAPK1ALDH1A1HTTKDM4E | |
| SCHEMBL13319460 | 0.78 | CYP3A4 (0.49) | SMN1; SMN2MAPK1CYP3A4MAPT | |
| SCHEMBL13319313 | 0.77 | CYP3A4 (0.49) | SMN1; SMN2MAPK1CYP3A4MAPT | |
| SCHEMBL13319018 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPK1ALDH1A1HTTKDM4E | |
| SCHEMBL13319337 | 0.76 | CYP3A4 (0.50) | SMN1; SMN2MAPK1CYP3A4MAPT | |
| SCHEMBL14469157 | 0.75 | CYP3A4 (0.53) | SMN1; SMN2MAPK1ALDH1A1HTTKDM4E | |
| SCHEMBL13319282 | 0.75 | CYP3A4 (0.51) | SMN1; SMN2MAPK1CYP3A4MAPT | |
| SCHEMBL14258764 | 0.75 | CYP3A4 (0.47) | CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144591-A1 | BENZIMIDAZOLE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144591-A1 | BENZIMIDAZOLE DERIVATIVES AND METHODS OF USE THEREOF | GPR119, GK, GCK | SMN1; SMN2 1534/4885MAPK1 2152/4885ALDH1A1 612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.