Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.60 |
| ▸ | RAD52 | P43351 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTR5A | P47898 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2980510 | 0.89 | SIRT2 (0.72) | SIRT2RAD52KMT2ATAAR1LMNA | |
| Hydrochloric Acid SCHEMBL11840237 | 0.88 | SIRT2 (0.71) | SIRT2RAD52KMT2ATAAR1LMNA | |
| SCHEMBL2301247 | 0.81 | SIRT2 (0.61) | SIRT2RAD52KMT2ATAAR1LMNA | |
| Hydrochloric Acid SCHEMBL31117467 | 0.80 | SIRT2 (0.76) | SIRT2RAD52KMT2ATAAR1LMNA | |
| SCHEMBL2241172 | 0.78 | RAD52 (0.59) | SIRT2RAD52KMT2ATAAR1LMNA | |
| SCHEMBL30228634 | 0.77 | TAAR1 (0.59) | SIRT2RAD52KMT2ATAAR1LMNA | |
| SCHEMBL2313213 | 0.77 | TAAR1 (0.59) | SIRT2RAD52KMT2ATAAR1LMNA | |
| SCHEMBL7818620 | 0.77 | LMNA (0.67) | SIRT2RAD52KMT2ALMNACYP1A2 | |
| SCHEMBL31020972 | 0.77 | SIRT2 (0.60) | SIRT2RAD52KMT2ATAAR1PARP1 | |
| SCHEMBL2243566 | 0.77 | PARP1 (0.67) | SIRT2RAD52KMT2ATAAR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100125085-A1 | PYRIDOINDOLE MODULATORS OF NMDA RECEPTOR AND ACETYLCHOLINESTERASE | AUSPEX PHARMACEUTICALS, INC. (US) | 2010-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100125085-A1 | PYRIDOINDOLE MODULATORS OF NMDA RECEPTOR AND ACETYLCHOLINESTERASE | GRIN3A, GRIK5, CHRNA5 | SIRT2 2988/4885RAD52 3984/4885KMT2A 1198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.