Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 3/20 | 0.59 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | BTK | Q06187 | 1/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | IGF1R | P08069 | 2/20 | 0.52 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.52 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.51 |
| ▸ | CCNK | O75909 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CCND3 | P30281 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3337236 | 0.91 | MAPK8 (0.66) | STAT6MAPK8MAPK9MAPK10EGFR | |
| SCHEMBL13320273 | 0.90 | PKMYT1 (0.56) | STAT6MAPK8MAPK9MAPK10FLT3 | |
| SCHEMBL13320859 | 0.89 | MAPK8 (0.57) | STAT6MAPK8MAPK9MAPK10FLT3 | |
| SCHEMBL13320864 | 0.86 | PKMYT1 (0.58) | STAT6MAPK8MAPK9MAPK10FLT3 | |
| SCHEMBL13321202 | 0.86 | EGFR (0.60) | STAT6MAPK8MAPK9MAPK10FLT3 | |
| SCHEMBL13320721 | 0.85 | FLT3 (0.60) | STAT6MAPK8MAPK9MAPK10FLT3 | |
| SCHEMBL13320722 | 0.85 | SYK (0.55) | STAT6MAPK8MAPK9MAPK10FLT3 | |
| SCHEMBL13320862 | 0.83 | GAA (0.56) | STAT6MAPK8MAPK9MAPK10FLT3 | |
| SCHEMBL13300731 | 0.83 | MAPK8 (0.64) | MAPK8MAPK9MAPK10EGFRIGF1R | |
| SCHEMBL13300728 | 0.83 | NTRK1 (0.71) | STAT6MAPK8MAPK9MAPK10EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144732-A1 | PYRIMIDINE KINASE INHIBITORS | GENENTECH, INC. | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144732-A1 | PYRIMIDINE KINASE INHIBITORS | DTYMK, DCK, TYMP | STAT6 784/4885MAPK8 532/4885MAPK9 256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.