DCK

Deoxycytidine kinase · P27707 · DCK on Sugi Atlas →

4,168 patent compounds predicted against DCK, 1,922 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL307979 SCHEMBL307979 1.00 20/20
SCHEMBL308191 SCHEMBL308191 1.00 20/20
SCHEMBL310854 SCHEMBL310854 1.00 20/20
SCHEMBL312736 SCHEMBL312736 1.00 20/20
SCHEMBL312043 SCHEMBL312043 0.86 20/20
SCHEMBL307480 SCHEMBL307480 0.83 20/20
SCHEMBL311255 SCHEMBL311255 0.79 20/20
SCHEMBL311352 SCHEMBL311352 0.79 20/20
SCHEMBL311924 SCHEMBL311924 0.79 20/20
SCHEMBL311662 SCHEMBL311662 0.78 20/20
SCHEMBL307563 SCHEMBL307563 0.78 20/20
SCHEMBL308017 SCHEMBL308017 0.74 20/20
SCHEMBL311256 SCHEMBL311256 0.73 20/20
SCHEMBL306525 SCHEMBL306525 0.73 20/20
SCHEMBL311500 SCHEMBL311500 0.72 20/20
SCHEMBL310844 SCHEMBL310844 0.71 20/20
SCHEMBL310972 SCHEMBL310972 0.71 20/20
SCHEMBL307463 SCHEMBL307463 0.71 20/20
SCHEMBL310971 SCHEMBL310971 0.70 20/20
SCHEMBL311696 SCHEMBL311696 0.69 20/20

Clinical trials — most relevant to DCK by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Acelarin First Line Randomised Pancreatic Study PHASE2/PHASE3SUSPENDED
Gemcitabine With or Without Bevacizumab in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer PHASE3COMPLETED
Clofarabine Plus Cytarabine in Patients With Previously Untreated Acute Myeloid Leukemia and High-risk Myelodysplastic Syndrome PHASE2COMPLETED
Autologous Cytokine Induced Killer Cells (CIK) for Chronic Myeloid Leukemia (CML) Patients on Standard Drug Therapy PHASE2COMPLETED
Safety, Tolerance, Pharmacokinetic and Antiviral Study of Amdoxovir in Combination With Zidovudine in Adults With HIV PHASE1/PHASE2COMPLETED
D-CIK Combined With Chemotherapy for Non-Small Cell Lung Cancer(NSCLC) PHASE1/PHASE2UNKNOWN
I/II Phase Study Evaluating M1774 in Combination With Fulvestrant in HR+ and HER2- Advanced Breast Cancers PHASE1/PHASE2NOT_YET_RECRUITING
Effect of Intratumoral Injection of Gene Therapy for Locally Advanced Pancreatic Cancer PHASE2COMPLETED
Bryostatin 1 in Treating Patients With Metastatic or Recurrent Head and Neck Cancer PHASE2COMPLETED
PKC412 and 5-Azacytidine PHASE1/PHASE2COMPLETED
Epirubicin, Docetaxel, and Capecitabine in Treating Women With Stage IIIA or Stage IIIB Breast Cancer PHASE2COMPLETED
PRO#0118: Decitabine Plus Mini Flu-Bu PHASE1COMPLETED
Open-Label, Dose-Escalation With Expansion to Assess the Safety, Tolerability, and PK of TRE-515 in Subjects With Solid Tumors PHASE1RECRUITING
Veliparib (ABT-888), an Oral PARP Inhibitor, and VX-970, an ATR Inhibitor, in Combination With Cisplatin in People With Refractory Solid Tumors PHASE1COMPLETED
AZD1775 for Advanced Solid Tumors PHASE1COMPLETED
Study of Cytolytic Viral Activation Therapy (CVAT) for Recurrent/Metastatic Nasopharyngeal Carcinoma PHASE1UNKNOWN
5-Fluoro-2'-Deoxcyctidine and Tetrahydrouridine to Treat Patients With Advanced Cancer PHASE1COMPLETED
Volasertib Combined With Induction Chemotherapy in Acute Myeloid Leukemia PHASE1WITHDRAWN
Pacritinib and Chemotherapy in Treating Patients With Acute Myeloid Leukemia and FLT3 Mutations PHASE1COMPLETED
Gemcitabine and Radiation Therapy in Treating Patients With Locally Advanced Upper Gastrointestinal Cancer PHASE1COMPLETED
A Safety, Tolerability and PK Study of DCC-2618 in Patients With Advanced Malignancies PHASE1COMPLETED
A Study of PD1 Combined With Dc-cik in the Treatment of Solid Tumors EARLY_PHASE1UNKNOWN
Defining the Triple Negative Breast Cancer Kinome Response to GSK1120212 EARLY_PHASE1COMPLETED
3'-Deoxy-3'-[18F] Fluorothymidine and Fludeoxyglucose F 18 PET Scans in Evaluating Response to Cetuximab, Cisplatin, and Radiation Therapy in Patients With Advanced Cancer of the Oropharynx, Larynx, or Hypopharynx EARLY_PHASE1COMPLETED
Thymidine Kinase 1 in Risk Assessment for Hereditary Breast /Ovarian Cancer nanUNKNOWN
RT201(Tumor Antigen-specific Macrophage Tumor Vaccine) nanUNKNOWN
Study of DC-CIK Combined With Chemotherapy for Advanced Solid Tumor nanUNKNOWN
Biomarkers in Blood and Tissue Samples From Patients With Epstein-Barr Virus-Positive Hodgkin Lymphoma nanCOMPLETED
Clinical Research for Azacitidine Combined With Low-dose Dasatinib in Maintenance Therapy of Acute Myeloid Leukemia nanUNKNOWN
Concurrent Chemoradiation With or Without DC-CIK Immunotherapy in Treating Locally Advanced Esophageal Cancer nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a DCK binder may also engage these)

ProteinNameSimilarity
Q3MHR2 1.000 Q3MHR2 →
Q5ZJM7 1.000 Q5ZJM7 →
P43346 1.000 P43346 →
P48769 1.000 P48769 →
Q5ZMF3 1.000 Q5ZMF3 →
Q6DD33 1.000 Q6DD33 →
A0A1L8HV70 0.998 A0A1L8HV70 →
Q6GPW6 0.992 Q6GPW6 →
P0DSV5 0.991 P0DSV5 →
Q9XZT6 0.991 Q9XZT6 →
A0A7H0DNE5 0.990 A0A7H0DNE5 →
P00572 0.990 P00572 →
Q9QX60 0.990 Q9QX60 →
Q8QQ21 0.990 Q8QQ21 →
Q80DS7 0.990 Q80DS7 →
P68693 0.990 P68693 →
P0DSV6 0.989 P0DSV6 →
Q16854 0.989 Q16854 →
Q77TG7 0.989 Q77TG7 →
Q76RA8 0.989 Q76RA8 →
P36590 0.987 P36590 →
Q8V2K9 0.987 Q8V2K9 →
Q9J579 0.987 Q9J579 →
Q6RZD4 0.987 Q6RZD4 →
Q8QMQ7 0.987 Q8QMQ7 →
Q9UTC5 0.987 Q9UTC5 →
P42938 0.986 P42938 →
Q80HT9 0.986 Q80HT9 →
Q9VZD2 0.986 Q9VZD2 →
Q09509 0.985 Q09509 →