Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR2 | O43603 | 2/20 | 0.40 |
| ▸ | GALR1 | P47211 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | JUN | P05412 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1332189 | 1.00 | GALR2 (0.40) | GALR2GALR1MAPK1MAPK6GRIN1 | |
| SCHEMBL1333952 | 0.89 | KDM4E (0.40) | MAPK1MAPK6GRIN1GRIN2BIRAK4 | |
| SCHEMBL1333948 | 0.89 | KDM4E (0.40) | MAPK1MAPK6GRIN1GRIN2BIRAK4 | |
| SCHEMBL1334058 | 0.86 | GALR2 (0.42) | GALR2GALR1MAPK1MAPK6IRAK4 | |
| SCHEMBL1334057 | 0.86 | GALR2 (0.42) | GALR2GALR1MAPK1MAPK6IRAK4 | |
| SCHEMBL1030129 | 0.85 | GALR2 (0.50) | GALR2GALR1MAPK1GAAHDAC6 | |
| SCHEMBL1029335 | 0.84 | GALR2 (0.52) | GALR2GALR1MAPK1GAAHDAC6 | |
| SCHEMBL1033809 | 0.82 | GALR2 (0.39) | GALR2GALR1MAPK1GRIN2BIRAK4 | |
| SCHEMBL1033807 | 0.82 | GALR2 (0.39) | GALR2GALR1MAPK1GRIN2BIRAK4 | |
| SCHEMBL1028909 | 0.81 | IDH1 (0.43) | GALR2GALR1HDAC6MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8513242-B2 | Pyrimidine compounds and methods of making and using same | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2013-08-20 | — | — | US | disclosed |
| US-20110281873-A1 | Pyrimidine Compounds and Methods of Making and Using Same | CYSTIC FIBROSIS FOUNDATION | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281873-A1 | Pyrimidine Compounds and Methods of Making and Using Same | CFTR, GPR17, TYMS | GALR2 4500/4885GALR1 4245/4885MAPK1 4410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.