Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.35 |
| ▸ | ACACB | O00763 | 3/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.35 |
| ▸ | ACACA | Q13085 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | JUN | P05412 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1333948 | 1.00 | KDM4E (0.40) | KDM4EALDH1A1MAPK6EGLN1MAP4K4 | |
| SCHEMBL1332189 | 0.89 | GALR2 (0.40) | ALDH1A1MAPK6GRIN1GRIN2BIRAK4 | |
| SCHEMBL1332192 | 0.89 | GALR2 (0.40) | ALDH1A1MAPK6GRIN1GRIN2BIRAK4 | |
| SCHEMBL1334209 | 0.86 | GRM5 (0.41) | KDM4EALDH1A1MAPK6EGLN1MAP4K4 | |
| SCHEMBL1334210 | 0.86 | GRM5 (0.41) | KDM4EALDH1A1MAPK6EGLN1MAP4K4 | |
| SCHEMBL1033079 | 0.86 | KDM4E (0.50) | KDM4EALDH1A1EGLN1MAP4K4CDK4 | |
| SCHEMBL1034806 | 0.85 | KDM4E (0.49) | KDM4EALDH1A1MAP4K4CDK4MAPK10 | |
| SCHEMBL1032982 | 0.82 | PTPN5 (0.37) | KDM4EALDH1A1MAPK6EGLN1MAP4K4 | |
| SCHEMBL12125234 | 0.82 | PTPN5 (0.37) | KDM4EALDH1A1MAPK6EGLN1MAP4K4 | |
| SCHEMBL1032981 | 0.82 | PTPN5 (0.37) | KDM4EALDH1A1MAPK6EGLN1MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8513242-B2 | Pyrimidine compounds and methods of making and using same | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2013-08-20 | — | — | US | disclosed |
| US-20110281873-A1 | Pyrimidine Compounds and Methods of Making and Using Same | CYSTIC FIBROSIS FOUNDATION | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281873-A1 | Pyrimidine Compounds and Methods of Making and Using Same | CFTR, GPR17, TYMS | KDM4E 4417/4885ALDH1A1 1880/4885MAPK6 3590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.