⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17680931 | 0.71 | CREBBP (0.62) | — | |
| SCHEMBL509355 | 0.69 | — | — | |
| SCHEMBL12160740 | 0.69 | — | — | |
| SCHEMBL357257 | 0.69 | — | — | |
| SCHEMBL18772594 | 0.67 | — | — | |
| SCHEMBL11279005 | 0.67 | — | — | |
| SCHEMBL18717440 | 0.67 | — | — | |
| SCHEMBL20614486 | 0.67 | CREBBP (0.52) | — | |
| SCHEMBL5153801 | 0.67 | — | — | |
| SCHEMBL6205330 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7713935-B2 | Compounds that modulate TRH actions | THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) | 2010-05-11 | — | — | US | disclosed |
| US-7378397-B2 | TRH-degrading ectoenzyme inhibitors | THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) | 2008-05-27 | — | — | US | disclosed |
| US-20070265202-A1 | Compounds That Modulate Trh Actions | THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE O (IE) | 2007-11-15 | — | — | US | disclosed |