Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | NCEH1 | Q6PIU2 | 2/20 | 0.56 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | FGB | P02675 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15077329 | 0.83 | MAPT (0.60) | MAPTCYP1A2CYP2C9CYP2C19NCEH1 | |
| SCHEMBL27740253 | 0.83 | MAPT (0.60) | MAPTCYP1A2CYP2C9CYP2C19NCEH1 | |
| SCHEMBL6286760 | 0.81 | NCEH1 (0.60) | MAPTCYP1A2CYP2C9CYP2C19NCEH1 | |
| SCHEMBL3274613 | 0.81 | MAPT (0.62) | MAPTCYP1A2CYP2C9CYP2C19NCEH1 | |
| SCHEMBL18686299 | 0.80 | MAPT (0.53) | MAPTCYP1A2CYP2C9CYP2C19TLR8 | |
| SCHEMBL29629320 | 0.80 | MAPT (0.53) | MAPTCYP1A2CYP2C9CYP2C19TLR8 | |
| SCHEMBL27782095 | 0.79 | MAPT (0.55) | MAPTCYP1A2CYP2C9CYP2C19NCEH1 | |
| SCHEMBL10136521 | 0.79 | NCEH1 (0.54) | MAPTCYP1A2CYP2C9CYP2C19NCEH1 | |
| SCHEMBL13390983 | 0.78 | MAPT (0.58) | MAPTCYP1A2CYP2C9CYP2C19NCEH1 | |
| SCHEMBL5610039 | 0.78 | MAPT (0.63) | MAPTCYP1A2CYP2C9CYP2C19NCEH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718612-B2 | Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2010-05-18 | — | — | US | disclosed |
| US-20090035272-A1 | Pyridazinonyl Macrocyclic Hepatitis C Serine Protease Inhibitors | ENANTA PHARMACEUTICALS, INC. | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090035272-A1 | Pyridazinonyl Macrocyclic Hepatitis C Serine Protease Inhibitors | PRSS1, SPINT2, TMPRSS4 | MAPT 4248/4885CYP1A2 241/4885CYP2C9 259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.