Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 10/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 9/20 | 0.59 |
| ▸ | RIPK1 | Q13546 | 6/20 | 0.59 |
| ▸ | AURKC | Q9UQB9 | 3/20 | 0.59 |
| ▸ | PLK4 | O00444 | 3/20 | 0.59 |
| ▸ | SRC | P12931 | 2/20 | 0.59 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.59 |
| ▸ | STK25 | O00506 | 1/20 | 0.59 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.59 |
| ▸ | GAK | O14976 | 1/20 | 0.59 |
| ▸ | MUSK | O15146 | 1/20 | 0.59 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.59 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.59 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.59 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | ERN1 | O75460 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13324827 | 0.89 | AURKB (0.61) | AURKAAURKBAURKCPLK4SRC | |
| SCHEMBL13220965 | 0.86 | AURKA (0.56) | AURKAAURKBRIPK1AURKCPLK4 | |
| SCHEMBL13324825 | 0.83 | AURKA (0.59) | AURKAAURKBRIPK1AURKCPLK4 | |
| SCHEMBL13220980 | 0.80 | AURKA (0.59) | AURKAAURKBRIPK1AURKCPLK4 | |
| SCHEMBL19990474 | 0.78 | AURKA (0.76) | AURKAAURKBRIPK1AURKCPLK4 | |
| SCHEMBL2957416 | 0.77 | AURKA (0.71) | AURKAAURKBRIPK1AURKCPLK4 | |
| SCHEMBL13220967 | 0.76 | AURKA (0.44) | AURKAAURKBRIPK1AURKCPLK4 | |
| SCHEMBL25638957 | 0.76 | AURKB (0.69) | AURKAAURKBRIPK1AURKCPLK4 | |
| SCHEMBL13004578 | 0.75 | AURKA (0.87) | AURKAAURKBRIPK1AURKCPLK4 | |
| SCHEMBL12430807 | 0.74 | AURKB (0.79) | AURKAAURKBRIPK1AURKCPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7713973-B2 | Kinase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-05-11 | — | — | US | disclosed |
| US-7713973-B2 | Kinase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-05-11 | — | — | US | disclosed |