Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13326788 | 0.91 | KCNH2 (0.56) | CCR5KCNH2 | |
| SCHEMBL5421632 | 0.91 | KCNH2 (0.56) | CCR5KCNH2 | |
| SCHEMBL5424497 | 0.87 | KCNH2 (0.58) | CCR5KCNH2 | |
| SCHEMBL14591186 | 0.81 | KCNH2 (0.57) | CCR5KCNH2 | |
| SCHEMBL4695421 | 0.81 | KCNH2 (0.47) | CCR5KCNH2 | |
| SCHEMBL14503409 | 0.80 | KCNH2 (0.55) | CCR5KCNH2 | |
| SCHEMBL13326789 | 0.80 | KCNH2 (0.66) | CCR5KCNH2 | |
| SCHEMBL5428611 | 0.77 | CCR5 (0.46) | CCR5KCNH2 | |
| SCHEMBL4694033 | 0.77 | KCNH2 (0.48) | CCR5KCNH2 | |
| SCHEMBL13326791 | 0.76 | CCR5 (0.63) | CCR5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7714018-B2 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC (US) | 2010-05-11 | — | — | US | disclosed |
| US-20070117859-A1 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC | 2007-05-24 | — | — | US | disclosed |
| US-7164019-B2 | Such as cyclopentanecarboxylic acid {(S)-1-phenyl-3-[5-(pyridine-3-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-propyl}-amide; antagonists of chemokine receptors, useful for treating/preventing human immunodeficiency virus infection, AIDS or ARC | ROCHE PALO ALTO LLC (US) | 2007-01-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070117859-A1 | Heterocyclic antiviral compounds | CCR5, ACKR3, CXCR1 | CCR5 1/4885KCNH2 3249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.