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CCR5

C-C chemokine receptor type 5 · P51681 · CCR5 on Sugi Atlas →

136,106 patent compounds predicted against CCR5, 66,439 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Maraviroc Maraviroc (SCHEMBL51991) 1.00 20/20
Vicriviroc Vicriviroc (SCHEMBL118885) 1.00 20/20
SCHEMBL175093 SCHEMBL175093 0.56 20/20
SCHEMBL174295 SCHEMBL174295 0.78 19/20
SCHEMBL174296 SCHEMBL174296 0.78 19/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL48548) 1.00 16/20
SCHEMBL95026 SCHEMBL95026 0.55 12/20
SCHEMBL221782 SCHEMBL221782 0.41 9/20
SCHEMBL190649 SCHEMBL190649 0.51 8/20
SCHEMBL179090 SCHEMBL179090 0.60 7/20
SCHEMBL109382 SCHEMBL109382 0.54 7/20
Phenanthroline Phenanthroline (SCHEMBL226209) 0.73 6/20
SCHEMBL82269 SCHEMBL82269 0.60 6/20
SCHEMBL80676 SCHEMBL80676 0.53 6/20
SCHEMBL178977 SCHEMBL178977 0.53 6/20
SCHEMBL178978 SCHEMBL178978 0.51 6/20
SCHEMBL148708 SCHEMBL148708 0.49 6/20
SCHEMBL108772 SCHEMBL108772 0.49 6/20
SCHEMBL66301 SCHEMBL66301 0.38 6/20
SCHEMBL66732 SCHEMBL66732 0.38 6/20

Clinical trials — most relevant to CCR5 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
CCR5 Inhibitor Treatment Intensification on CD4+ T-cell Recovery PHASE4COMPLETED
Leronlimab in Patients With Coronavirus Disease 2019 (COVID-19) With Need for Mechanical Ventilation or Extracorporeal Membrane Oxygenation PHASE3SUSPENDED
Leronlimab in Moderately Ill Patients With COVID-19 Pneumonia PHASE3SUSPENDED
Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized) PHASE3UNKNOWN
PRO 140 in Treatment-Experienced HIV-1 Subjects PHASE2/PHASE3COMPLETED
Safety and Efficacy Study of Intravenous Immunoglobulin to Treat Japanese Encephalitis PHASE2COMPLETED
Effect of Cenicriviroc on HIV Neurocognitive Impairment PHASE2COMPLETED
Trial of Allogeneic Reduced-Intensity, HLA-Haploidentical Allogeneic Hematopoietic Cell Bone Marrow Transplantation Followed by Graft-versus-Host-Disease (GVHD) Prophylaxis With Cyclophosphamide, Bortezomib and Maraviroc for Hematologic Malignancies ... PHASE1/PHASE2RECRUITING
Safety Study of a Chemokine Receptor (CXCR4) Antagonist in Multiple Myeloma Patients PHASE1/PHASE2COMPLETED
Allogeneic Transplant in HIV Patients (BMT CTN 0903) PHASE2COMPLETED
Aerosol Combination Therapy of All-trans Retinoic Acid and Isotretinoin as A Novel Treatment for Inducing Neutralizing Antibodies in COVID -19 Infected Patients Better Than Vaccine : An Innovative Treatment PHASE2UNKNOWN
Effects of Maraviroc (MVC) on HIV-related Kaposi's Sarcoma (KS) PHASE2COMPLETED
A Phase I Trial Anti-CC Chemokine Receptor 4 Chimeric Antigen Receptor T Cells (CCR4 CAR T Cells) for CCR4 Expressing T-cell Malignancies Including Peripheral T-cell Non-Hodgkin Lymphoma (PTCL) and Cutaneous T-cell Non-Hodgkin Lymphoma (CTCL) PHASE1RECRUITING
Maraviroc in Patients With Moderate and Severe COVID-19 PHASE1COMPLETED
Adoptive Transfer of Haploidentical NK Cells and N-803 PHASE1COMPLETED
Safety and Tolerability of PRO 140 in HIV Uninfected Male Volunteers PHASE1COMPLETED
Genetic Polymorphism Associated With Coronary Heart Disease Susceptibility and Variability of Clopidogrel Response nanACTIVE_NOT_RECRUITING
Immunology Dysregulation in Lymphadenitis Tuberculosis : An Observational Study Using Patient' Block Paraffins 2019 Until 2021 nanCOMPLETED
Evaluation of CCR6 Gene Expression and Circulating CCL20 Levels as Potential Biomarkers in Rheumatoid Arthritis nanNOT_YET_RECRUITING
The Role of SDF-1/CXCR4 in Metastasis of Oral Squamous Cell Carcinoma nanUNKNOWN
The Role of MMPs in the CXCL12-Induced Invasion of Laryngeal and Hypopharyngeal Squamous Cell Carcinoma nanUNKNOWN
Circular RNA and Chemerin in Breast Cancer Patient nanUNKNOWN
Value of Various Chemokines in the Detection and Follow up of RCC nanUNKNOWN
Evaluation of Macrophage Inflammatory Protein-1α as a Periodontal Disease Biomarker nanCOMPLETED
Evaluating Urinary CXCL10 for Enhanced Detection of Acute Rejection in Kidney Transplant Patients With Low DD-CFDNA nanRECRUITING
C-X-C Chemokine Receptor 4 in Chronic Lymphocytic Leukemia nanUNKNOWN
Inflammatory Biomarkers in Psychogenic Non-epileptic Seizure nanUNKNOWN
Inflammatory Biomarkers in Seizure nanUNKNOWN
A Study That Collects Participant Data and Biospecimens to Analyze Pathogenic Exosomes That Mediate Increased Vascular Dementia Risk in Individuals With Herpes Zoster. nanRECRUITING
The Role of Stromal Cell-Derived Factor-1 (SDF-1)/CXC Chemokine Receptor 4 (CXCR4) in Metastasis of Laryngeal and Hypopharyngeal Squamous Cell Carcinoma nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a CCR5 binder may also engage these)

ProteinNameSimilarity
Q95ND1 — 1.000 Q95ND1 →
O97882 — 1.000 O97882 →
Q95NC1 — 1.000 Q95NC1 →
O62743 — 1.000 O62743 →
Q95ND2 — 1.000 Q95ND2 →
P61815 — 1.000 P61815 →
P56493 — 1.000 P56493 →
P56439 — 1.000 P56439 →
Q95ND0 — 1.000 Q95ND0 →
Q95NC6 — 1.000 Q95NC6 →
Q95NC0 — 1.000 Q95NC0 →
Q9TV48 — 1.000 Q9TV48 →
Q95NC8 — 1.000 Q95NC8 →
P61755 — 1.000 P61755 →
O97881 — 1.000 O97881 →
P61814 — 1.000 P61814 →
P61813 — 1.000 P61813 →
Q95NE8 — 1.000 Q95NE8 →
Q9TV47 — 1.000 Q9TV47 →
O97878 — 1.000 O97878 →
Q95NC5 — 1.000 Q95NC5 →
P68269 — 1.000 P68269 →
Q9BGN6 — 1.000 Q9BGN6 →
P61756 — 1.000 P61756 →
Q9TV42 — 1.000 Q9TV42 →
O97975 — 1.000 O97975 →
P60574 — 1.000 P60574 →
P56440 — 1.000 P56440 →
P68270 — 1.000 P68270 →
Q95NC3 — 1.000 Q95NC3 →