Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | UBE2M | P61081 | 3/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.35 |
| ▸ | GIPR | P48546 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14960509 | 1.00 | RXFP1 (0.42) | RXFP1HSD17B10UBE2MDCUN1D1CYP1A2 | |
| SCHEMBL18790161 | 1.00 | RXFP1 (0.42) | RXFP1HSD17B10UBE2MDCUN1D1CYP1A2 | |
| SCHEMBL14959092 | 0.94 | RXFP1 (0.42) | RXFP1HSD17B10UBE2MDCUN1D1CYP1A2 | |
| SCHEMBL15088237 | 0.94 | RXFP1 (0.37) | RXFP1UBE2MDCUN1D1CYP1A2CYP2C9 | |
| SCHEMBL15088254 | 0.92 | EPHX2 (0.39) | RXFP1UBE2MDCUN1D1ALDH1A1ACKR3 | |
| SCHEMBL17805408 | 0.92 | ACKR3 (0.39) | RXFP1UBE2MDCUN1D1LMNAALDH1A1 | |
| SCHEMBL14960520 | 0.92 | ACKR3 (0.39) | RXFP1UBE2MDCUN1D1LMNAALDH1A1 | |
| SCHEMBL18790160 | 0.92 | ACKR3 (0.39) | RXFP1UBE2MDCUN1D1LMNAALDH1A1 | |
| SCHEMBL18790138 | 0.91 | GCGR (0.39) | RXFP1UBE2MDCUN1D1ALDH1A1USP2 | |
| SCHEMBL20879839 | 0.91 | GCGR (0.39) | RXFP1UBE2MDCUN1D1ALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3078658-B1 | C5AR ANTAGONISTS | CHEMOCENTRYX INC (US) | 2019-04-10 | — | — | EP | disclosed |
| US-20170065604-A1 | C5aR ANTAGONISTS | CHEMOCENTRYX, INC. | 2017-03-09 | — | — | US | disclosed |
| US-20100160320-A1 | C5aR ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160320-A1 | C5aR ANTAGONISTS | C5AR1, C5AR2, C3AR1 | RXFP1 911/4885HSD17B10 4597/4885UBE2M 4268/4885 |
| US-20170065604-A1 | C5aR ANTAGONISTS | C5AR1, C5AR2, C3AR1 | RXFP1 892/4885HSD17B10 4551/4885UBE2M 4188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.