Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | UBE2M | P61081 | 4/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | GIPR | P48546 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18790161 | 0.94 | RXFP1 (0.42) | RXFP1HSD17B10UBE2MDCUN1D1CYP1A2 | |
| SCHEMBL14960509 | 0.94 | RXFP1 (0.42) | RXFP1HSD17B10UBE2MDCUN1D1CYP1A2 | |
| SCHEMBL13327392 | 0.94 | RXFP1 (0.42) | RXFP1HSD17B10UBE2MDCUN1D1CYP1A2 | |
| SCHEMBL14959087 | 0.92 | ACKR3 (0.40) | RXFP1UBE2MDCUN1D1LMNAALDH1A1 | |
| SCHEMBL14959102 | 0.90 | UBE2M (0.40) | RXFP1UBE2MDCUN1D1ALDH1A1USP2 | |
| SCHEMBL14959097 | 0.90 | MAPK14 (0.38) | RXFP1HSD17B10UBE2MDCUN1D1CYP1A2 | |
| SCHEMBL24016857 | 0.89 | HSD17B10 (0.46) | RXFP1HSD17B10UBE2MDCUN1D1CYP1A2 | |
| SCHEMBL14959019 | 0.89 | HSD17B10 (0.46) | RXFP1HSD17B10UBE2MDCUN1D1CYP1A2 | |
| SCHEMBL18609695 | 0.89 | HSD17B10 (0.46) | RXFP1HSD17B10UBE2MDCUN1D1CYP1A2 | |
| SCHEMBL15088229 | 0.89 | RXFP1 (0.38) | RXFP1HSD17B10UBE2MDCUN1D1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445515-B2 | C5aR antagonists | CHEMOCENTRYX, INC. (US) | 2013-05-21 | — | — | US | disclosed |