Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 20/20 | 0.77 |
| ▸ | TPH2 | Q8IWU9 | 11/20 | 0.77 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.77 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.77 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.77 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.77 |
| ▸ | CCKAR | P32238 | 2/20 | 0.77 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.77 |
| ▸ | F2 | P00734 | 1/20 | 0.77 |
| ▸ | ESR1 | P03372 | 1/20 | 0.77 |
| ▸ | DRD1 | P21728 | 1/20 | 0.77 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.77 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.77 |
| ▸ | DRD3 | P35462 | 1/20 | 0.77 |
| ▸ | MLNR | O43193 | 1/20 | 0.66 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.66 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.66 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.66 |
| ▸ | MC3R | P41968 | 1/20 | 0.66 |
| ▸ | HTR3A | P46098 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL613469 | 0.92 | TPH1 (0.78) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL613770 | 0.92 | TPH1 (0.78) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL613268 | 0.92 | TPH1 (0.78) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL613470 | 0.92 | TPH1 (0.78) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL613468 | 0.92 | TPH1 (0.78) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL610574 | 0.91 | TPH1 (0.89) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL612946 | 0.91 | TPH1 (0.89) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL610573 | 0.91 | TPH1 (0.89) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL19672627 | 0.91 | TPH1 (0.89) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL869896 | 0.90 | TPH1 (0.83) | TPH1TPH2ADORA3SLC6A2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010065333-A1 | 4-PHENYL-6-(2,2,2-TRIFLUORO-1-PHENYLETHOXY)PYRIMIDINE-BASED COMPOUNDS FOR THE TREATMENT OF OSTEOPOROSIS | LEXICON PHARMACEUTICALS, INC. (US) | 2010-06-10 | — | — | WO | disclosed |