Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 8/20 | 0.40 |
| ▸ | RARB | P10826 | 8/20 | 0.40 |
| ▸ | RARG | P13631 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.38 |
| ▸ | RELA | Q04206 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2495280 | 0.94 | NPC1 (0.44) | RARARARBRARGMAPTTP53 | |
| SCHEMBL3339957 | 0.88 | RARA (0.39) | RARARARBRARGMAPTTP53 | |
| SCHEMBL2494462 | 0.84 | NPC1 (0.42) | RARARARBRARGMAPTTP53 | |
| SCHEMBL13331063 | 0.83 | NPC1 (0.39) | RARARARBRARGMAPTALDH1A1 | |
| SCHEMBL13330598 | 0.81 | SMN1; SMN2 (0.53) | MAPTTP53TSHRALDH1A1LMNA | |
| SCHEMBL3341615 | 0.80 | NPC1 (0.51) | RARARARBRARGMAPTALDH1A1 | |
| SCHEMBL2505933 | 0.80 | NPC1 (0.41) | RARARARBRARGMAPTALDH1A1 | |
| SCHEMBL13303772 | 0.80 | NPC1 (0.41) | RARARARBRARGMAPTALDH1A1 | |
| SCHEMBL13330603 | 0.80 | NPC1 (0.41) | MAPTALDH1A1LMNANPC1RAB9A | |
| SCHEMBL3342970 | 0.79 | NPC1 (0.47) | RARARARBRARGMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010065760-A1 | IMIDAZO [1,2A] PYRIDINE DERIVATIVES, THEIR USE AS S1P1 AGONISTS AND METHODS FOR THEIR PRODUCTION | EXELIXIS, INC. (US) | 2010-06-10 | — | — | WO | disclosed |