Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | IL1RN | P18510 | 1/20 | 0.72 |
| ▸ | APEX1 | P27695 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.62 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.60 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11713864 | 0.87 | MAPT (0.74) | MAPTIL1RNAPEX1KMT2AMEN1 | |
| SCHEMBL14696960 | 0.86 | ALDH1A1 (0.78) | MAPTIL1RNAPEX1KMT2AMEN1 | |
| SCHEMBL3931238 | 0.85 | MAPT (0.70) | MAPTIL1RNAPEX1KMT2AMEN1 | |
| SCHEMBL26144941 | 0.85 | MAPT (0.66) | MAPTIL1RNAPEX1KMT2AMEN1 | |
| SCHEMBL26144942 | 0.85 | MAPT (0.66) | MAPTIL1RNAPEX1KMT2AMEN1 | |
| SCHEMBL3932198 | 0.84 | MAPT (0.94) | MAPTIL1RNAPEX1KMT2AMEN1 | |
| SCHEMBL1001486 | 0.84 | MAPT (1.00) | MAPTIL1RNAPEX1KMT2AMEN1 | |
| SCHEMBL29463849 | 0.84 | MAPT (1.00) | MAPTIL1RNAPEX1KMT2AMEN1 | |
| SCHEMBL30695457 | 0.83 | MAPT (0.67) | MAPTIL1RNAPEX1KMT2AMEN1 | |
| SCHEMBL4251683 | 0.82 | MAPT (0.97) | MAPTIL1RNAPEX1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061602-A1 | ISOINDOLINONE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2012-05-10 | — | — | WO | disclosed |
| US-20110275630-A1 | ISOINDOLINONE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275630-A1 | ISOINDOLINONE KINASE INHIBITORS | MAP3K7, MAP3K5, MAP3K20 | MAPT 1836/4885IL1RN 1550/4885APEX1 3478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.