Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 15/20 | 0.90 |
| ▸ | CA12 | O43570 | 13/20 | 0.90 |
| ▸ | CA1 | P00915 | 13/20 | 0.90 |
| ▸ | CA9 | Q16790 | 13/20 | 0.90 |
| ▸ | CA7 | P43166 | 4/20 | 0.90 |
| ▸ | TSHR | P16473 | 1/20 | 0.90 |
| ▸ | CA4 | P22748 | 4/20 | 0.65 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8618402 | 1.00 | CA2 (0.90) | CA2CA12CA1CA9CA7 | |
| SCHEMBL9848224 | 1.00 | CA2 (0.90) | CA2CA12CA1CA9CA7 | |
| SCHEMBL6550862 | 1.00 | CA2 (0.90) | CA2CA12CA1CA9CA7 | |
| SCHEMBL10822914 | 1.00 | CA2 (0.90) | CA2CA12CA1CA9CA7 | |
| SCHEMBL1376263 | 0.98 | CA2 (0.93) | CA2CA12CA1CA9CA7 | |
| SCHEMBL615392 | 0.95 | CA2 (1.00) | CA2CA12CA1CA9CA7 | |
| SCHEMBL19891669 | 0.91 | CA12 (0.79) | CA2CA12CA1CA9CA7 | |
| SCHEMBL28817746 | 0.89 | CA1 (0.70) | CA2CA12CA1CA9CA7 | |
| SCHEMBL5595956 | 0.87 | CA1 (1.00) | CA2CA12CA1CA9CA7 | |
| SCHEMBL28005088 | 0.87 | CA1 (0.72) | CA2CA12CA1CA9CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150290200-A1 | INTRACELLULAR KINASE INHIBITORS | PHARMACYCLICS INC (US) | 2015-10-15 | — | — | US | disclosed |
| EP-2865381-A1 | ITK inhibitors for treating blood cell malignancies | Pharmacyclics, Inc. (US) | 2015-04-29 | — | — | EP | disclosed |
| US-20140080833-A1 | INTRACELLULAR KINASE INHIBITORS | MANNKIND CORPORATION (US) | 2014-03-20 | — | — | US | disclosed |
| US-8604031-B2 | Intracellular kinase inhibitors | MANNKIND CORPORATION (US) | 2013-12-10 | — | — | US | disclosed |
| US-20110281850-A1 | INTRACELLULAR KINASE INHIBITORS | MANNKIND CORPORATION (US) | 2011-11-17 | — | — | US | disclosed |
| EP-2027087-A2 | INTRACELLULAR KINASE INHIBITORS | MannKind Corporation (US) | 2009-02-25 | — | — | EP | disclosed |
| US-20070293499-A1 | Intracellular Kinase Inhibitors | MANNKIND CORPORATION (US) | 2007-12-20 | — | — | US | disclosed |
| WO-2007136790-A2 | INTRACELLULAR KINASE INHIBITORS | MANNKIND CORPORATION (US) | 2007-11-29 | — | — | WO | disclosed |
| US-20040220054-A1 | Recording material | FUJI PHOTO FILM CO., LTD. | 2004-11-04 | — | — | US | disclosed |
| EP-1473591-A1 | Recording material | FUJI PHOTO FILM CO., LTD. (JP) | 2004-11-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293499-A1 | Intracellular Kinase Inhibitors | PI4KB, BTK, LTK | CA2 1861/4885CA12 3959/4885CA1 2887/4885 |
| US-20150290200-A1 | INTRACELLULAR KINASE INHIBITORS | PI4KB, BTK, LTK | CA2 1861/4885CA12 3959/4885CA1 2887/4885 |
| US-20110281850-A1 | INTRACELLULAR KINASE INHIBITORS | PI4KB, BTK, LTK | CA2 1861/4885CA12 3959/4885CA1 2887/4885 |
| US-20140080833-A1 | INTRACELLULAR KINASE INHIBITORS | PI4KB, BTK, LTK | CA2 1861/4885CA12 3959/4885CA1 2887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.