SCHEMBL13337707

SCHEMBL13337707

COc1cc(Nc2nc(-c3ccc4c(c3)NC=C=N4)cn3ccnc23)ccc1OC(C)C

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SYK P43405 20/20 0.58
CD63 P08962 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2480304 0.80 SYK (0.68) SYKCD63
SCHEMBL2898306 0.80 SYK (0.58) SYKCD63
SCHEMBL2898302 0.78 SYK (0.63) SYKCD63
SCHEMBL3791215 0.78 SYK (0.88) SYKCD63
SCHEMBL2482812 0.75 SYK (0.75) SYKCD63
SCHEMBL2483250 0.74 SYK (0.77) SYKCD63
SCHEMBL2483010 0.74 SYK (0.81) SYKCD63
SCHEMBL2478843 0.74 SYK (0.70) SYKCD63
SCHEMBL2478983 0.73 SYK (0.75) SYKCD63
SCHEMBL2480707 0.73 SYK (0.75) SYKCD63

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010068257-A1 IMIDAZOPYRAZINE SYK INHIBITORS CGI PHARMACEUTICALS, INC. (US) 2010-06-17 WO disclosed