Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2482722 | 0.93 | SYK (0.71) | SYKCD63 | |
| SCHEMBL2484485 | 0.89 | SYK (0.64) | SYKCD63 | |
| SCHEMBL2524412 | 0.86 | SYK (0.71) | SYKCD63 | |
| SCHEMBL2480304 | 0.83 | SYK (0.68) | SYKCD63 | |
| SCHEMBL2478946 | 0.83 | SYK (0.64) | SYKCD63 | |
| SCHEMBL19503278 | 0.80 | SYK (0.61) | SYKCD63 | |
| SCHEMBL3791215 | 0.80 | SYK (0.88) | SYKCD63 | |
| SCHEMBL2898306 | 0.80 | SYK (0.58) | SYKCD63 | |
| SCHEMBL13337679 | 0.79 | SYK (0.59) | SYKCD63 | |
| SCHEMBL12016084 | 0.79 | SYK (0.58) | SYKCD63 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9212191-B2 | 6-(2,3-dihydro-1H-pyrido-[2,3-b][1,4]oxazin-7-yl)-N-(4-morpholinophenyl)imidazo[1,2-a] pyrazin-8-amine as a spleen tyrosine kinase inhibitor | GILEAD CONNECTICUT, INC. (US) | 2015-12-15 | — | — | US | disclosed |
| US-8455493-B2 | Imidazopyrazine Syk inhibitors | GILEAD CONNECTICUT, INC. (US) | 2013-06-04 | — | — | US | disclosed |
| US-20100222323-A1 | IMIDAZOPYRAZINE SYK INHIBITORS | Kronos Bio, Inc. | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222323-A1 | IMIDAZOPYRAZINE SYK INHIBITORS | SYK, BTK, ZAP70 | SYK 1/4885CD63 2977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.