Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL3 | Q96JM7 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | MBTD1 | Q05BQ5 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11024494 | 0.89 | SMN1; SMN2 (0.41) | HTR6KDM4EALDH1A1SMN1; SMN2L3MBTL3 | |
| SCHEMBL24221676 | 0.89 | SMN1; SMN2 (0.41) | HTR6KDM4EALDH1A1SMN1; SMN2L3MBTL3 | |
| SCHEMBL1439628 | 0.88 | KDM4E (0.36) | HTR6KDM4EALDH1A1L3MBTL3L3MBTL1 | |
| SCHEMBL24770316 | 0.88 | KDM4E (0.36) | HTR6KDM4EALDH1A1L3MBTL3L3MBTL1 | |
| SCHEMBL18207814 | 0.88 | SMN1; SMN2 (0.35) | HTR6KDM4EALDH1A1SMN1; SMN2L3MBTL3 | |
| SCHEMBL2358820 | 0.86 | SMN1; SMN2 (0.42) | HTR6KDM4EALDH1A1SMN1; SMN2L3MBTL3 | |
| SCHEMBL16878171 | 0.86 | L3MBTL3 (0.38) | HTR6KDM4EALDH1A1L3MBTL3L3MBTL1 | |
| SCHEMBL14529673 | 0.86 | KDM2B (0.36) | HTR6KDM4EALDH1A1SMN1; SMN2L3MBTL3 | |
| SCHEMBL2115253 | 0.84 | — | — | |
| SCHEMBL12065889 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023159148-A2 | INHIBITORS OF NLRP3 | PTC THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |