Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 3/20 | 0.33 |
| ▸ | ITK | Q08881 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 4/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.30 |
| ▸ | AHR | P35869 | 1/20 | 0.30 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3462090 | 0.79 | S1PR1 (0.38) | ITKS1PR1S1PR3 | |
| SCHEMBL13263031 | 0.77 | S1PR1 (0.44) | ITKAURKAS1PR1S1PR3 | |
| SCHEMBL30629157 | 0.77 | RIPK1 (0.32) | ITKRIPK1 | |
| SCHEMBL30629099 | 0.77 | ITK (0.34) | ITKMEN1KMT2AMAPTHPGD | |
| SCHEMBL2476418 | 0.76 | S1PR1 (0.36) | ITKS1PR1S1PR3 | |
| SCHEMBL2543824 | 0.76 | S1PR1 (0.36) | NPC1RAB9AMAPTHSD11B1TP53 | |
| SCHEMBL13262772 | 0.75 | S1PR1 (0.43) | ITKS1PR1S1PR3 | |
| SCHEMBL1861990 | 0.73 | S1PR1 (0.55) | NPC1RAB9AMAPTTP53S1PR1 | |
| SCHEMBL13262879 | 0.71 | S1PR1 (0.38) | ALPLITKS1PR1S1PR3 | |
| SCHEMBL2470310 | 0.71 | S1PR1 (0.43) | ITKS1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2202232-A1 | 1,2,4-oxadiazole derivatives and their therapeutic use | Laboratorios Almirall, S.A. (ES) | 2010-06-30 | — | — | EP | disclosed |