Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | CHKA | P35790 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.50 |
| ▸ | VEGFA | P15692 | 1/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | LSS | P48449 | 1/20 | 0.49 |
| ▸ | PPARD | Q03181 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5569584 | 0.89 | GPR119 (0.58) | SMN1; SMN2HTTNPSR1MAPTLMNA | |
| SCHEMBL18210853 | 0.88 | SMN1; SMN2 (0.54) | SMN1; SMN2HTTNPSR1MAPTLMNA | |
| SCHEMBL1722245 | 0.88 | SMN1; SMN2 (0.57) | SMN1; SMN2HTTNPSR1MAPTLMNA | |
| SCHEMBL13369337 | 0.85 | SMN1; SMN2 (0.54) | SMN1; SMN2HTTNPSR1MAPTLMNA | |
| SCHEMBL5573222 | 0.83 | MAPT (0.76) | SMN1; SMN2HTTNPSR1MAPTLMNA | |
| SCHEMBL21659284 | 0.82 | MAPT (0.53) | SMN1; SMN2HTTNPSR1MAPTLMNA | |
| SCHEMBL25218845 | 0.82 | VEGFA (0.54) | SMN1; SMN2HTTNPSR1MAPTLMNA | |
| SCHEMBL3807661 | 0.82 | MAPT (0.64) | SMN1; SMN2HTTNPSR1MAPTLMNA | |
| SCHEMBL2858333 | 0.82 | TP53 (0.58) | SMN1; SMN2MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL5536182 | 0.82 | VEGFA (0.68) | SMN1; SMN2HTTNPSR1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709492-B2 | Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists | SCHERING CORPORATION (US) | 2010-05-04 | — | — | US | disclosed |