SCHEMBL13344783

SCHEMBL13344783

CC[C@@H](Nc1nonc1Nc1cccc(C(=O)N(C)C)c1O)c1ccccc1

nearest known ligand 0.75

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CXCR2 P25025 20/20 0.75
CXCR1 P25024 18/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14639802 0.91 CXCR2 (0.70) CXCR2CXCR1
SCHEMBL13208124 0.86 CXCR2 (1.00) CXCR2CXCR1
SCHEMBL13344780 0.86 CXCR2 (0.70) CXCR2CXCR1
SCHEMBL13206994 0.85 CXCR2 (0.74) CXCR2CXCR1
SCHEMBL14619898 0.84 CXCR2 (0.67) CXCR2CXCR1
SCHEMBL13345046 0.84 CXCR2 (0.67) CXCR2CXCR1
SCHEMBL12779694 0.83 CXCR2 (0.72) CXCR2CXCR1
SCHEMBL13345260 0.83 CXCR2 (0.66) CXCR2CXCR1
SCHEMBL13344833 0.83 CXCR2 (0.69) CXCR2CXCR1
SCHEMBL13344829 0.82 CXCR2 (0.60) CXCR2CXCR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7718678-B2 Di-substituted oxadiazoles as CXC-chemokine receptor ligands SCHERING CORPORATION (US) 2010-05-18 US disclosed
US-7718678-B2 Di-substituted oxadiazoles as CXC-chemokine receptor ligands SCHERING CORPORATION (US) 2010-05-18 US disclosed
US-20070004682-A1 Di-substituted oxadiazoles as CXC-chemokine receptor ligands SCHERING CORPORATION 2007-01-04 US disclosed
US-20070004682-A1 Di-substituted oxadiazoles as CXC-chemokine receptor ligands SCHERING CORPORATION 2007-01-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070004682-A1 Di-substituted oxadiazoles as CXC-chemokine receptor ligands CXCR3, CXCR1, CXCR2 CXCR2 3/4885CXCR1 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.