Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15756197 | 0.94 | KMT2A (0.55) | KMT2AMEN1GAAUSP2TAAR1 | |
| SCHEMBL23011090 | 0.89 | KMT2A (0.55) | KMT2AMEN1GAAUSP2TAAR1 | |
| SCHEMBL18664437 | 0.88 | DPP8 (0.45) | KMT2AMEN1GAAUSP2TAAR1 | |
| SCHEMBL24682514 | 0.85 | MEN1 (0.61) | KMT2AMEN1GAAUSP2TAAR1 | |
| SCHEMBL14421980 | 0.84 | DRD2 (0.51) | KDM4EALOX15HDAC3HDAC1HDAC8 | |
| SCHEMBL12277163 | 0.82 | PRMT5 (0.45) | KMT2AMEN1GAAUSP2TAAR1 | |
| SCHEMBL20883859 | 0.82 | MEN1 (0.47) | KMT2AMEN1GAAUSP2TAAR1 | |
| SCHEMBL12269219 | 0.82 | KMT2A (0.49) | KMT2AMEN1GAAUSP2TAAR1 | |
| SCHEMBL12706824 | 0.81 | S1PR1 (0.45) | KMT2AMEN1GAAUSP2TAAR1 | |
| SCHEMBL3477555 | 0.80 | HDAC3 (0.70) | KMT2AMEN1USP2TAAR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376484-B1 | OXADIAZOLE FUSED HETEROCYCLIC DERIVATIVES USEFUL FOR THE TREATMENT OF MULTIPLE SCLEROSIS | MERCK SERONO SA (CH) | 2015-04-22 | — | — | EP | disclosed |
| WO-2010069949-A1 | OXADIAZOLE FUSED HETEROCYCLIC DERIVATIVES USEFUL FOR THE TREATMENT OF MULTIPLE SCLEROSIS | MERCK SERONO S.A. (CH) | 2010-06-24 | — | — | WO | disclosed |