Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | EIF4E | P06730 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.35 |
| ▸ | DDX3X | O00571 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2636570 | 0.88 | MGAM (0.42) | MGAMGAASIMGAM2S1PR1 | |
| SCHEMBL2636936 | 0.88 | MGAM (0.42) | MGAMGAASIMGAM2S1PR1 | |
| SCHEMBL12167548 | 0.88 | MGAM (0.42) | MGAMGAASIMGAM2S1PR1 | |
| SCHEMBL221258 | 0.88 | MGAM (0.42) | MGAMGAASIMGAM2S1PR1 | |
| SCHEMBL12342536 | 0.88 | MGAM (0.42) | MGAMGAASIMGAM2S1PR1 | |
| SCHEMBL12342538 | 0.88 | MGAM (0.45) | MGAMGAASIMGAM2S1PR1 | |
| SCHEMBL2482859 | 0.83 | S1PR1 (0.44) | MGAMGAASIMGAM2S1PR1 | |
| SCHEMBL221374 | 0.82 | MGAM (0.45) | MGAMGAASIMGAM2PTGES | |
| SCHEMBL2835437 | 0.78 | S1PR1 (0.46) | GAAS1PR1S1PR3MAPTLMNA | |
| SCHEMBL2551204 | 0.78 | S1PR1 (0.46) | MGAMGAASIMGAM2S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010071853-A1 | THIAZOLOPYRIDINE SIRTUIN MODULATING COMPOUNDS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2010-06-24 | — | — | WO | disclosed |
| WO-2008156869-A2 | SIRTUIN MODULATING THIAZOLOPYRIDINE COMPOUNDS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |