Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 9/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 7/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14876625 | 1.00 | S1PR1 (0.46) | S1PR1S1PR3MAPK1GRM2LTA4H | |
| SCHEMBL2482859 | 0.87 | S1PR1 (0.44) | S1PR1S1PR3KMT2AMGAMGAA | |
| SCHEMBL14877364 | 0.84 | S1PR1 (0.47) | S1PR1S1PR3GRM2LTA4HKMT2A | |
| SCHEMBL14877363 | 0.84 | S1PR1 (0.47) | S1PR1S1PR3GRM2LTA4HKMT2A | |
| SCHEMBL2835443 | 0.82 | S1PR1 (0.46) | S1PR1S1PR3KMT2AGAA | |
| SCHEMBL2835437 | 0.82 | S1PR1 (0.46) | S1PR1S1PR3KMT2AGAA | |
| SCHEMBL12342538 | 0.78 | MGAM (0.45) | S1PR1S1PR3MGAMGAASI | |
| SCHEMBL221258 | 0.78 | MGAM (0.42) | S1PR1S1PR3KMT2AMGAMGAA | |
| SCHEMBL2636936 | 0.78 | MGAM (0.42) | S1PR1S1PR3KMT2AMGAMGAA | |
| SCHEMBL12342536 | 0.78 | MGAM (0.42) | S1PR1S1PR3MGAMGAASI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2993236-A1 | SIRTUIN ACTIVATORS AND ACTIVATION ASSAYS | Glaxosmithkline LLC (US) | 2016-03-09 | — | — | EP | disclosed |
| US-20130102009-A1 | SIRTUIN ACTIVATORS AND ACTIVATION ASSAYS | GLAXOSMITHKLINE LLC | 2013-04-25 | — | — | US | disclosed |
| EP-2558589-A2 | SIRTUIN ACTIVATORS AND ACTIVATION ASSAYS | Sirtris Pharmaceuticals, Inc. (US) | 2013-02-20 | — | — | EP | disclosed |
| WO-2011130595-A2 | SIRTUIN ACTIVATORS AND ACTIVATION ASSAYS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2011-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130102009-A1 | SIRTUIN ACTIVATORS AND ACTIVATION ASSAYS | SIRT1, SIRT7, SIRT2 | S1PR1 4265/4885S1PR3 3951/4885MAPK1 2385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.