Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 19/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13346177 | 0.95 | ATR (0.51) | ATR | |
| SCHEMBL13347155 | 0.82 | ATR (0.52) | ATR | |
| SCHEMBL20433601 | 0.81 | ATR (0.53) | ATR | |
| SCHEMBL19672753 | 0.80 | ATR (0.60) | ATR | |
| SCHEMBL19672698 | 0.79 | ATR (0.55) | ATR | |
| SCHEMBL20433577 | 0.79 | ATR (0.52) | ATR | |
| SCHEMBL20433393 | 0.77 | ATR (0.56) | ATR | |
| SCHEMBL20433187 | 0.77 | ATR (0.43) | ATRMTOR | |
| SCHEMBL13346030 | 0.74 | ATR (0.52) | ATR | |
| SCHEMBL19672750 | 0.74 | ATR (0.57) | ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010071837-A1 | PYRAZINE DERIVATIVES USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-06-24 | — | — | WO | disclosed |