Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 7/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20433209 | 0.81 | ATR (0.47) | ATRMTORPIK3CA | |
| SCHEMBL24681817 | 0.80 | ATR (0.63) | ATRMTORPIK3CA | |
| SCHEMBL24248212 | 0.80 | ATR (0.57) | ATR | |
| SCHEMBL13346207 | 0.77 | ATR (0.53) | ATRMTOR | |
| SCHEMBL20432976 | 0.77 | ATR (0.55) | ATRMTORPIK3CA | |
| SCHEMBL20433508 | 0.77 | ATR (0.46) | ATRMTORPIK3CADGAT1 | |
| SCHEMBL24681422 | 0.74 | ATR (0.47) | ATRMTORPIK3CA | |
| SCHEMBL20433073 | 0.73 | ATR (0.40) | ATR | |
| SCHEMBL18180976 | 0.72 | ATR (0.51) | ATRMTORPIK3CA | |
| SCHEMBL13346177 | 0.71 | ATR (0.51) | ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4059932-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | Vertex Pharmaceuticals Incorporated (US) | 2022-09-21 | — | — | EP | disclosed |
| EP-3354650-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | Vertex Pharmaceuticals Incorporated (US) | 2018-08-01 | — | — | EP | disclosed |