Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.32 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | PDE8B | O95263 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 2/20 | 0.30 |
| ▸ | CTSD | P07339 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2768416 | 0.83 | MAP4K4 (0.31) | IKBKBPIK3CDMAP4K4 | |
| SCHEMBL2767551 | 0.83 | PAX8 (0.33) | IKBKBPIK3CDMAP4K4CDK1 | |
| SCHEMBL3880903 | 0.82 | CDK1 (0.34) | MAP4K4CDK1 | |
| SCHEMBL2768343 | 0.82 | CSF1R (0.38) | IKBKB | |
| SCHEMBL12344427 | 0.79 | CDK1 (0.36) | IKBKBCDK1 | |
| SCHEMBL12344385 | 0.78 | BRD4 (0.38) | IKBKB | |
| SCHEMBL12341871 | 0.75 | GRM4 (0.32) | — | |
| SCHEMBL13463910 | 0.74 | BRD4 (0.39) | IKBKBTNK2 | |
| SCHEMBL12344450 | 0.74 | IKBKB (0.32) | IKBKB | |
| SCHEMBL12344495 | 0.74 | FNTA (0.37) | IKBKBMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737279-B2 | 1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-06-15 | — | — | US | disclosed |