PAX8

Paired box protein Pax-8 · Q06710 · PAX8 on Sugi Atlas →

119,802 patent compounds predicted against PAX8, 77,612 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Zorubicin (SCHEMBL168293)	0.61	6/20
Zorubicin (SCHEMBL8231)	0.84	5/20
Zorubicin (SCHEMBL8232)	0.84	5/20
SCHEMBL162675	0.82	5/20
Esorubicin (SCHEMBL3864)	0.81	5/20
Rodorubicin (SCHEMBL8693)	0.47	5/20
SCHEMBL134456	0.44	5/20
Aclarubicin (SCHEMBL97477)	0.43	5/20
Epirubicin (SCHEMBL3165)	1.00	4/20
Doxorubicin (SCHEMBL3242)	1.00	4/20
Digoxigenin (SCHEMBL21105)	1.00	4/20
Doxorubicin (SCHEMBL57097)	1.00	4/20
Doxorubicin (SCHEMBL177976)	1.00	4/20
Idarubicin (SCHEMBL4838)	0.98	4/20
Carubicin (SCHEMBL4201)	0.85	4/20
Zorubicin (SCHEMBL4023)	0.83	4/20
Zorubicin (SCHEMBL4024)	0.83	4/20
Pirarubicin (SCHEMBL99651)	0.79	4/20
Amrubicin (SCHEMBL9140)	0.57	4/20
Amrubicin (SCHEMBL119022)	0.57	4/20

Clinical trials — most relevant to PAX8 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
Azacitidine After Allo Blood And Marrow Transplantation (BMT) for Chronic Myelogenous Leukemia (CML)	PHASE2	COMPLETED
Open-label Trial of SUBA™-Itraconazole (SUBA-Cap) in Subjects With Basal Cell Carcinoma Nevus Syndrome (BCCNS)	PHASE2	COMPLETED
Claudin18.2-redirected Chimeric Antigen Receptor T Cells With Co-expression of Cytokines in Solid Tumors	PHASE1	UNKNOWN
Biomarkers in Patients With Advanced Rhabdomyosarcoma	nan	COMPLETED
Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis.	nan	COMPLETED
Biomarkers to Distinguish Benign From Malignant Thyroid Neoplasm	nan	COMPLETED
Cervical Cytology DNA Methylation for Cervical Cancer Screening	nan	NOT_YET_RECRUITING
Patients With RETT Syndrome	nan	UNKNOWN
The Role of TBX3 in Human ES Cell Differentiation	nan	WITHDRAWN
B3 for NMD: Bench to Bedside and Back	nan	ENROLLING_BY_INVITATION
Study of Neurodegenerative Diseases Induced Stem Cells in Patients and Healthy Family Controls.	nan	UNKNOWN
Pathophysiology of Diabetic Gastroparesis	nan	UNKNOWN
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients	nan	RECRUITING
Genetic Analysis and Multimodal Retinal Imaging of Asymptomatic Fovea Plana Cases in the General Population	nan	COMPLETED
Overcoming TWEAK Signaling to Restore Muscle and Mobility After Joint Replacement	nan	COMPLETED
Evaluation of Blood Vessel Formation in Endocrine Tumors	nan	COMPLETED
Role of HIF-1α in Skeletal Muscle Aging	nan	UNKNOWN
Molecular and Immunohistochemical Profiling of Tumors in Patients With Parathyroid Tumors	nan	RECRUITING
Studying Protein Expression in Tissue Samples From Younger Patients With Rhabdomyosarcoma	nan	COMPLETED
Genetic Clues to Chordoma Etiology: A Protocol to Identify Sporadic Chordoma Patients for Studies of Cancer-Susceptibility Genes	nan	ACTIVE_NOT_RECRUITING
The Etiology and Progression of Brain Tumors	nan	COMPLETED
Evaluation of the Regeneration Capacity of Satellite Cells From the Quadriceps Compared to That of the Diaphragm	nan	COMPLETED
Positioning of Molecular Markers in Clinical Routine for the Management of Patients With Adrenal Cancers/Tumors (COMETE-CARE)	nan	RECRUITING
The Detection and Factors of Brown Adipose Tissue in Different Locations of Adults	nan	UNKNOWN
Mechanisms of Inherited Retinal Dystrophies Using Whole Genome Sequencing and in Vitro and in Vivo Models	nan	COMPLETED
Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Myelodysplastic Syndrome Low Risk	nan	COMPLETED
Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders	nan	COMPLETED
Intrauterine Environment in Polycystic Ovary Syndrome (PCOS) Probands	nan	COMPLETED
An Investigation of Pituitary Tumors and Related Hypothalmic Disorders	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a PAX8 binder may also engage these)

Protein	Name	Similarity
P47240	—	1.000	P47240 →
Q00288	—	1.000	Q00288 →
P32114	—	1.000	P32114 →
P51974	—	1.000	P51974 →
Q90268	—	1.000	Q90268 →
O57682	—	1.000	O57682 →
O57685	—	1.000	O57685 →
A0JMA6	—	1.000	A0JMA6 →
Q2VL58	—	1.000	Q2VL58 →
PAX3	Paired box protein Pax-3 (HuP2)	1.000	landscape →
Q5R9M8	—	1.000	Q5R9M8 →
Q2VL62	—	1.000	Q2VL62 →
Q2VL59	—	1.000	Q2VL59 →
Q1KKW8	—	1.000	Q1KKW8 →
Q2VL57	—	1.000	Q2VL57 →
Q645N4	—	0.999	Q645N4 →
PAX2	Paired box protein Pax-2	0.999	landscape →
Q2L4T2	—	0.998	Q2L4T2 →
Q2VL60	—	0.998	Q2VL60 →
Q2VL50	—	0.998	Q2VL50 →
O13023	—	0.997	O13023 →
Q66IK1	—	0.996	Q66IK1 →
Q9U903	—	0.996	Q9U903 →
Q98876	—	0.996	Q98876 →
P50575	—	0.996	P50575 →
P50574	—	0.996	P50574 →
P23759	—	0.996	P23759 →
Q2VL52	—	0.996	Q2VL52 →
Q60430	—	0.996	Q60430 →
Q26263	—	0.995	Q26263 →