Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.38 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | ACACA | Q13085 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13106525 | 0.91 | CHRM4 (0.40) | HRH3ACACA | |
| SCHEMBL13106629 | 0.90 | P2RY12 (0.42) | DHODHADAM17 | |
| SCHEMBL13097135 | 0.90 | PRMT5 (0.44) | ADAM17PRMT5IKBKBCHUK | |
| SCHEMBL13106516 | 0.89 | HRH3 (0.44) | HRH3ACACA | |
| SCHEMBL13106528 | 0.87 | NAMPT (0.43) | HRH3DHODHADAM17CYP2D6 | |
| SCHEMBL13097142 | 0.82 | FAAH (0.42) | HRH3DHODHPRMT5 | |
| SCHEMBL13349888 | 0.81 | CYSLTR1 (0.55) | DHODHCYP2D6GPBAR1CYSLTR2CYSLTR1 | |
| SCHEMBL13107296 | 0.80 | SLC2A1 (0.45) | ADAM17 | |
| SCHEMBL13096966 | 0.80 | ACP1 (0.43) | PRMT5ACACA | |
| SCHEMBL13349918 | 0.80 | F10 (0.49) | CYP2D6ACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367702-B2 | Quinolone derivative | ASTELLAS PHARMA INC. (JP) | 2013-02-05 | — | — | US | disclosed |
| EP-2194044-A1 | QUINOLONE DERIVATIVE | Astellas Pharma Inc. (JP) | 2010-06-09 | — | — | EP | disclosed |