Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 11/20 | 0.62 |
| ▸ | TOP1 | P11387 | 3/20 | 0.56 |
| ▸ | PDE4A | P27815 | 10/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.55 |
| ▸ | TERT | O14746 | 1/20 | 0.53 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SNCA | P37840 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30614194 | 0.83 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL2908650 | 0.83 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL717213 | 0.80 | PDE4D (0.66) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL15085259 | 0.77 | PDE4D (0.77) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL3237987 | 0.77 | TYK2 (0.60) | PDE4DPDE4APDE4BPDE4CTYK2 | |
| SCHEMBL15270505 | 0.77 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL720381 | 0.76 | PDE4D (0.73) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL4037514 | 0.76 | PDE4D (0.56) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL13350268 | 0.75 | PDE4D (0.67) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL1553996 | 0.75 | PDE4D (0.61) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822929-B1 | PROCESS FOR PREPARATION OF ROFLUMILAST | SCINOPHARM (CHANGSHU) PHARMACEUTICALS LTD (CN) | 2017-06-14 | — | — | EP | disclosed |
| WO-2012155812-A1 | PROCESSES FOR THE PREPARATION OF ROFLUMILAST AND INTERMEDIATES THEREOF | 上海特化医药科技有限公司 (CN) | 2012-11-22 | — | — | WO | disclosed |
| EP-2193808-A1 | Synergistic combination | Nycomed GmbH (DE) | 2010-06-09 | — | — | EP | disclosed |
| EP-1849468-A2 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | Nycomed GmbH (DE) | 2007-10-31 | — | — | EP | disclosed |