Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Buserelin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR known ✓ | P30968 | 2/20 | 0.68 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.63 |
| ▸ | C5AR1 | P21730 | 2/20 | 0.55 |
| ▸ | APLNR | P35414 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Buserelin SCHEMBL6676660 | 1.00 | GNRHR (0.68) | GNRHRABCC2PTGS1C5AR1APLNR | |
| Buserelin SCHEMBL29833854 | 1.00 | GNRHR (0.68) | GNRHRABCC2PTGS1C5AR1APLNR | |
| Buserelin SCHEMBL16766450 | 1.00 | GNRHR (0.68) | GNRHRABCC2PTGS1C5AR1APLNR | |
| Buserelin SCHEMBL14193133 | 1.00 | GNRHR (0.68) | GNRHRABCC2PTGS1C5AR1APLNR | |
| Buserelin SCHEMBL21806129 | 0.99 | ABCC2 (0.70) | GNRHRABCC2PTGS1C5AR1APLNR | |
| Buserelin SCHEMBL167553 | 0.99 | ABCC2 (0.70) | GNRHRABCC2PTGS1C5AR1APLNR | |
| Goserelin SCHEMBL8836302 | 0.98 | GNRHR (0.66) | GNRHRABCC2PTGS1C5AR1APLNR | |
| SCHEMBL29833903 | 0.97 | GNRHR (0.64) | GNRHRABCC2PTGS1C5AR1APLNR | |
| SCHEMBL29833823 | 0.97 | GNRHR (0.62) | GNRHRABCC2PTGS1APLNR | |
| Buserelin SCHEMBL3467577 | 0.96 | GNRHR (0.75) | GNRHRABCC2PTGS1APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 38950 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3841097-B1 | 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER | BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS BRFAA (GR) | 2026-05-20 | — | — | EP | claimed |
| US-20260124148-A1 | POLYPEPTIDE FORMULATIONS FOR ORAL DELIVERY | BHAMIS RES LABORATORY PVT LTD (IN) | 2026-05-07 | — | — | US | claimed |
| US-20260108619-A1 | CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2026-04-23 | — | — | US | claimed |
| US-20260109699-A1 | AZOLE DERIVATIVES AS SHP2 INHIBITORS | IRBM S.P.A. (IT) | 2026-04-23 | — | — | US | claimed |
| EP-3515892-B1 | COMPOUNDS AND METHODS FOR IDO AND TDO MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2026-04-15 | — | — | EP | claimed |
| US-12595293-B2 | Anti-follicle stimulating hormone receptor antibodies | THE WISTAR INSTITUTE (US) | 2026-04-07 | — | — | US | claimed |
| US-12577255-B2 | MDM2-based modulators of proteolysis and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2026-03-17 | — | — | US | claimed |
| EP-4704832-A2 | BIFUNCTIONAL SMALL MOLECULES TO TARGET THE SELECTIVE DEGRADATION OF CIRCULATING PROTEINS | Biohaven Therapeutics Ltd. (VG) | 2026-03-11 | — | — | EP | claimed |
| US-20260027062-A1 | IMPROVED ORAL PHARMACEUTICAL FORMULATIONS OF THERAPEUTIC PEPTIDES AND PROTEINS | CYPRUMED GMBH (AT) | 2026-01-29 | — | — | US | claimed |
| US-12533321-B2 | Polypeptide formulations for oral delivery | Bhami's Research Laboratory, Pvt. Ltd. (IN) | 2026-01-27 | — | — | US | claimed |
| WO-1991016929-A1 | A PHARMACEUTICAL PREPARATION CONTAINING N-GLYCOFUROLS AND N-ETHYLENE GLYCOLS | NOVO NORDISK A/S (DK) | 1991-11-14 | — | — | WO | claimed |
| WO-1991008795-A2 | IMPROVED IONTOPHORETIC DELIVERY METHOD | ALZA CORPORATION (US) | 1991-06-27 | — | — | WO | claimed |
| CN-1048659-A | The preparation method of aqueogel and xerogel preparation | HOECHST JAPAN (JP) | 1991-01-23 | — | — | CN | claimed |
| WO-1990014839-A1 | A PROCESS FOR TREATING INFERTILITY AND AN AGENT FOR USE IN THE PROCESS | NOVO NORDISK A/S (DK) | 1990-12-13 | — | — | WO | claimed |
| EP-0386688-A1 | Method for preparing hydrogel preparations and xerogel preparations | HOECHST JAPAN LIMITED (JP) | 1990-09-12 | — | — | EP | claimed |
| EP-0315875-A1 | Process for preparing biodegradable microcapsules containing peptides and proteins soluble in water and microcapsules obtained by said process | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-05-17 | — | — | EP | claimed |
| EP-0312052-A1 | Intranasal administration of polypeptides in powdered form | SYNTEX (U.S.A.) INC. (US) | 1989-04-19 | — | — | EP | claimed |
| EP-0262583-A1 | Parenteral depot preparations containing a calcium acetate-glycerol adduct for regulatory peptides | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-04-06 | — | — | EP | claimed |
| CN-86101573-A | The novel collector that is used for the mineral froth flotation | — | 1987-06-03 | — | — | CN | claimed |
| EP-0158277-A2 | Implantable controlled-release preparations of regulatory peptides, and process for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-10-16 | — | — | EP | claimed |