Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ACACA | Q13085 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13560074 | 0.86 | MAPT (0.40) | MAPTGAAKDM4EACACAALDH1A1 | |
| SCHEMBL13560075 | 0.86 | TP53 (0.33) | ADORA1 | |
| SCHEMBL2994362 | 0.77 | MAPT (0.44) | MAPTGAAKDM4EACACAALDH1A1 | |
| SCHEMBL2995547 | 0.77 | MAPT (0.44) | MAPTGAAKDM4EACACAALDH1A1 | |
| SCHEMBL3008995 | 0.76 | MAPT (0.43) | MAPTGAAKDM4EACACAALDH1A1 | |
| SCHEMBL3007349 | 0.76 | L3MBTL1 (0.44) | MAPTGAAKDM4EACACAALDH1A1 | |
| SCHEMBL3001072 | 0.76 | ADORA1 (0.45) | MAPTGAAKDM4EALDH1A1RXFP1 | |
| SCHEMBL2989298 | 0.75 | MAPT (0.42) | MAPTGAAKDM4EACACAALDH1A1 | |
| SCHEMBL3001775 | 0.75 | MAPT (0.43) | MAPTGAAKDM4EACACAALDH1A1 | |
| SCHEMBL2998082 | 0.70 | ADORA1 (0.46) | MAPTKDM4EALDH1A1ADORA1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778243-B1 | SUBSTITUTED AZEPINE DERIVATIVES AS SEROTONIN RECEPTOR MODULATORS | ATHERSYS INC (US) | 2012-10-31 | — | — | EP | disclosed |
| US-7718647-B2 | Substituted azepine derivatives as serotonin receptor modulators | ATHERSYS, INC. (US) | 2010-05-18 | — | — | US | disclosed |