Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 8/20 | 0.68 |
| ▸ | PDPK1 | O15530 | 8/20 | 0.68 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.68 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP1 | P63208 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12119823 | 0.91 | AURKA (0.63) | AURKAPDPK1AURKBEIF2AK4SYK | |
| SCHEMBL13354730 | 0.91 | PDPK1 (0.56) | AURKAPDPK1AURKBEIF2AK4SYK | |
| SCHEMBL12119819 | 0.87 | AURKA (0.67) | AURKAPDPK1AURKBEIF2AK4 | |
| SCHEMBL12119825 | 0.86 | AURKA (0.58) | AURKAPDPK1AURKBEIF2AK4BTK | |
| SCHEMBL13354875 | 0.84 | AURKA (0.52) | AURKAPDPK1AURKBEIF2AK4SYK | |
| SCHEMBL12119818 | 0.83 | AURKA (0.63) | AURKAPDPK1AURKBEIF2AK4MAP4K4 | |
| SCHEMBL13354797 | 0.81 | PDPK1 (0.60) | AURKAPDPK1AURKBEIF2AK4SYK | |
| SCHEMBL12119828 | 0.81 | PDPK1 (0.78) | AURKAPDPK1AURKBEIF2AK4BTK | |
| SCHEMBL12119820 | 0.81 | PDPK1 (1.00) | AURKAPDPK1AURKB | |
| SCHEMBL12119836 | 0.80 | AURKA (0.51) | AURKAPDPK1AURKBEIF2AK4SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059658-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-05-27 | — | — | WO | disclosed |