Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 10/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.60 |
| ▸ | AURKA | O14965 | 9/20 | 0.60 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.37 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.37 |
| ▸ | ITGAL | P20701 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13354730 | 0.91 | PDPK1 (0.56) | PDPK1AURKBAURKAEIF2AK4SYK | |
| SCHEMBL12119839 | 0.88 | AURKA (0.54) | PDPK1AURKBAURKAEIF2AK4SYK | |
| SCHEMBL12122733 | 0.87 | AURKA (0.60) | PDPK1AURKBAURKASYKBTK | |
| SCHEMBL13354875 | 0.87 | AURKA (0.52) | PDPK1AURKBAURKAEIF2AK4SYK | |
| SCHEMBL12119836 | 0.85 | AURKA (0.51) | PDPK1AURKBAURKAEIF2AK4SYK | |
| SCHEMBL12119838 | 0.84 | PDPK1 (0.84) | PDPK1AURKBAURKAPIK3CGROCK1 | |
| SCHEMBL12119841 | 0.82 | AURKA (0.47) | PDPK1AURKBAURKAEIF2AK4SYK | |
| SCHEMBL13354794 | 0.81 | AURKA (0.68) | PDPK1AURKBAURKAEIF2AK4SYK | |
| SCHEMBL12119819 | 0.81 | AURKA (0.67) | PDPK1AURKBAURKAEIF2AK4 | |
| SCHEMBL12119831 | 0.80 | AURKA (0.51) | PDPK1AURKBAURKAEIF2AK4BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059658-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-05-27 | — | — | WO | disclosed |