Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 20/20 | 0.83 |
| ▸ | KIT | P10721 | 5/20 | 0.82 |
| ▸ | FLT3 | P36888 | 5/20 | 0.82 |
| ▸ | CSF1R | P07333 | 3/20 | 0.82 |
| ▸ | PLK4 | O00444 | 1/20 | 0.82 |
| ▸ | GAK | O14976 | 1/20 | 0.82 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.82 |
| ▸ | STK10 | O94804 | 1/20 | 0.82 |
| ▸ | EGFR | P00533 | 1/20 | 0.82 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.82 |
| ▸ | LCK | P06239 | 1/20 | 0.82 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.82 |
| ▸ | SRC | P12931 | 1/20 | 0.82 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.82 |
| ▸ | FLT1 | P17948 | 1/20 | 0.82 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.82 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.82 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.82 |
| ▸ | AXL | P30530 | 1/20 | 0.82 |
| ▸ | FLT4 | P35916 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13168045 | 0.94 | PDGFRB (0.83) | PDGFRBKITFLT3CSF1RPLK4 | |
| SCHEMBL13330543 | 0.93 | PDGFRB (0.83) | PDGFRBKITFLT3CSF1RPLK4 | |
| SCHEMBL3315768 | 0.92 | PDGFRB (0.81) | PDGFRBKITFLT3CSF1RPLK4 | |
| SCHEMBL906256 | 0.92 | PDGFRB (0.81) | PDGFRBKITFLT3CSF1RPLK4 | |
| SCHEMBL12694513 | 0.91 | PDGFRB (0.83) | PDGFRBKITFLT3CSF1RPLK4 | |
| SCHEMBL906260 | 0.91 | PDGFRB (0.80) | PDGFRBKITFLT3CSF1RPLK4 | |
| SCHEMBL906352 | 0.91 | PDGFRB (0.80) | PDGFRBKITFLT3CSF1RPLK4 | |
| SCHEMBL906259 | 0.91 | PDGFRB (0.80) | PDGFRBKITFLT3CSF1RPLK4 | |
| Tandutinib SCHEMBL29393910 | 0.90 | PDGFRB (1.00) | PDGFRBKITFLT3CSF1RPLK4 | |
| Tandutinib SCHEMBL927974 | 0.90 | PDGFRB (1.00) | PDGFRBKITFLT3CSF1RPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709640-B2 | Nitrogenous heterocyclic compounds and process for making nitrogenous heterocyclic compounds and intermediates thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-05-04 | — | — | US | disclosed |