Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 2/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | PRKACA | P17612 | 1/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | AKT1 | P31749 | 1/20 | 0.52 |
| ▸ | AKT2 | P31751 | 1/20 | 0.52 |
| ▸ | GSK3A | P49840 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.52 |
| ▸ | PRKX | P51817 | 1/20 | 0.52 |
| ▸ | NEK4 | P51957 | 1/20 | 0.52 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7895007 | 0.85 | CHEK1 (0.41) | CLK2DYRK1ACLK4CHEK1ROCK2 | |
| SCHEMBL22320268 | 0.78 | GAA (0.50) | MAPK1ALDH1A1POLBGAAMAPT | |
| SCHEMBL9208078 | 0.78 | GAA (0.52) | SMN1; SMN2ALDH1A1POLBGAAMAPT | |
| SCHEMBL7894007 | 0.76 | POLB (0.37) | ROCK2CHEK2PRKACARPS6KB1MAPK1 | |
| SCHEMBL12092541 | 0.75 | CHEK2 (0.49) | CLK2DYRK1ACLK4CHEK1ROCK2 | |
| SCHEMBL7599186 | 0.75 | CHEK2 (0.55) | CLK2DYRK1ACLK4CHEK1ROCK2 | |
| SCHEMBL7895099 | 0.75 | LOXL2 (0.46) | CLK4CHEK1CHEK2PRKACARPS6KB1 | |
| SCHEMBL31155173 | 0.75 | MAPT (0.50) | SMN1; SMN2ALDH1A1POLBGAAMAPT | |
| SCHEMBL7603199 | 0.74 | CHEK2 (0.58) | CLK2DYRK1ACLK4CHEK1ROCK2 | |
| SCHEMBL7597388 | 0.74 | CHEK2 (0.54) | CLK2DYRK1ACLK4CHEK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010057101-A2 | COMPOUNDS USEFUL AS HIV BLOCKERS | SCHERING CORPORATION (US) | 2010-05-20 | — | — | WO | disclosed |