Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 20/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12313690 | 0.90 | DGAT1 (0.55) | DGAT1 | |
| SCHEMBL12314810 | 0.83 | DGAT1 (0.77) | DGAT1 | |
| SCHEMBL2393689 | 0.83 | DGAT1 (0.70) | DGAT1 | |
| SCHEMBL2145144 | 0.83 | DGAT1 (0.76) | DGAT1 | |
| SCHEMBL2408683 | 0.83 | DGAT1 (0.69) | DGAT1 | |
| SCHEMBL2145922 | 0.82 | DGAT1 (0.58) | DGAT1 | |
| SCHEMBL2145925 | 0.82 | DGAT1 (0.58) | DGAT1 | |
| SCHEMBL2395396 | 0.82 | DGAT1 (0.70) | DGAT1 | |
| SCHEMBL2145571 | 0.82 | DGAT1 (1.00) | DGAT1 | |
| SCHEMBL2393743 | 0.81 | DGAT1 (0.79) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716312-B2 | Inhibitors of diacylglycerol acyltransferase | MERCK SHARP & DOHME CORPORATION (US) | 2014-05-06 | — | — | US | disclosed |
| WO-2010059602-A2 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | SCHERING CORPORATION (US) | 2010-05-27 | — | — | WO | disclosed |