Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.73 |
| ▸ | LYN | P07948 | 1/20 | 0.63 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 4/20 | 0.44 |
| ▸ | SCARB1 | Q8WTV0 | 6/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13797993 | 0.90 | MAPK14 (0.74) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL4001894 | 0.89 | MAPK14 (0.73) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13797938 | 0.89 | MAPK14 (0.73) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13797943 | 0.88 | MAPK14 (0.72) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13810713 | 0.87 | MAPK14 (0.70) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13797952 | 0.86 | MAPK14 (0.72) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13797996 | 0.86 | MAPK14 (0.69) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13797936 | 0.85 | MAPK14 (0.68) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13359242 | 0.85 | MAPK14 (0.68) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13797949 | 0.85 | MAPK14 (0.68) | MAPK14LYNMAPK9BRAFSCARB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497278-B1 | HETEROCYCLIC AMIDE DERIVATIVES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2010-05-26 | — | — | EP | disclosed |
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |