Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.68 |
| ▸ | LYN | P07948 | 1/20 | 0.59 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.59 |
| ▸ | BRAF | P15056 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SCARB1 | Q8WTV0 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13359213 | 0.87 | MAPK14 (0.60) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13797993 | 0.86 | MAPK14 (0.74) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13797941 | 0.86 | MAPK14 (0.68) | MAPK14LYNMAPK9BRAFNPC1 | |
| SCHEMBL13359286 | 0.86 | MAPK14 (0.49) | MAPK14LYNMAPK9NPC1MAPK1 | |
| SCHEMBL13797938 | 0.85 | MAPK14 (0.73) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL4001894 | 0.85 | MAPK14 (0.73) | MAPK14LYNMAPK9BRAFSMN1; SMN2 | |
| SCHEMBL13359122 | 0.85 | MAPK14 (0.73) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13797996 | 0.85 | MAPK14 (0.69) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13797966 | 0.85 | MAPK14 (0.60) | MAPK14LYNMAPK9NPC1RAB9A | |
| SCHEMBL13797943 | 0.85 | MAPK14 (0.72) | MAPK14LYNMAPK9BRAFSCARB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |